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Merck
CN

PHR1493

盐酸毛果芸香碱

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

毛果芸香碱 盐酸盐, (3S,4R)-4,5-二氢-3-乙基-4-(1-甲基-1H-咪唑-5-基甲基)-2(3H)-呋喃酮 盐酸盐

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关于此项目

经验公式（希尔记法）:
C11H16N2O2 · HCl
化学文摘社编号:
54-71-7
分子量:
244.72
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823415
EC Number:
200-212-5
Beilstein/REAXYS Number:
4034491
MDL number:
MFCD00012722

主要文件

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InChI

1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1

InChI key

RNAICSBVACLLGM-GNAZCLTHSA-N

SMILES string

Cl.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. P1650000, traceable to USP 1538902

API family

pilocarpine

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

202-205 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... CHRM1(1128), CHRM3(1131)

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相关类别

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Pilocarpine Hydrochloride may be used as a pharmaceutical reference standard for the determination of pilocarpine in opthalmic dispersions and serum samples by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

非选择性毒蕈碱型乙酰胆碱受体激动剂；用于诱导癫痫实验模型。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3041 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Determination of pilocarpine by HPLC in presence of isopilocarpine a pH-sensitive polymer in ophthalmic dispersions
Ibrahim H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 5(4), 379-382 (1987)
Simple chemiluminescence determination of pilocarpine in pharmaceuticals and human serum.
Keyvanfard M, et al.
Acta Chimica Slovenica, 58(3), 379-382 (2011)

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