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Merck
CN

PHR1503

西洛他唑

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Cilostazol, 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC 13013, OPC 21, Pletaal

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关于此项目

经验公式（希尔记法）:
C20H27N5O2
化学文摘社编号:
73963-72-1
分子量:
369.46
NACRES:
NA.24
PubChem Substance ID:
329823424
UNSPSC Code:
41116107
MDL number:
MFCD00866780

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产品名称

西洛他唑, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)

SMILES string

O=C1CCc2cc(OCCCCc3nnnn3C4CCCCC4)ccc2N1

InChI key

RRGUKTPIGVIEKM-UHFFFAOYSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1134153

API family

cilostazol

CofA

current certificate can be downloaded

packaging

package of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... PDE3A(5139)

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Cilostazol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cilostazol is a dihydro-quinolinone derivative, that is predominantly used as an anti-platelet and vasodilatory agent. It acts by inhibition of cyclic adenosine monophosphate (cAMP) phosphodiesterase, which results in elevation of cAMP levels in platelets and blood vessels, thus inhibiting platelets aggregation.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3090 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361d

Hazard Classifications

Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Cilostazol (Pletal ?): a dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptake
Liu YS, et al.
Cardiovascular Drug Reviews, 19(4), 369-386 (2001)
HPLC determination of cilostazol in tablets, and its validation
Lestari AD, et al.
Journal of Liquid Chromatography and Related Technologies, 27(16), 2603-2612 (2004)
Validated stability-indicating methods for determination of cilostazol in the presence of its degradation products according to the ICH guidelines
Fayed AS, et al.
Journal of Pharmaceutical and Biomedical Analysis, 45(3), 407-416 (2007)

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