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Merck
CN

PHR1572

盐酸羟甲唑啉

certified reference material, pharmaceutical secondary standard

别名:

羟甲唑啉 盐酸盐, 2-（3-羟基-2,6-二甲基-4-叔丁基苄基）-2-咪唑啉 盐酸盐

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关于此项目

经验公式（希尔记法）:
C16H24N2O · HCl
化学文摘社编号:
2315-02-8
分子量:
296.84
NACRES:
NA.24
PubChem Substance ID:
329823480
UNSPSC Code:
41116107
EC Number:
219-015-0
MDL number:
MFCD00058147

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产品名称

盐酸羟甲唑啉, certified reference material, pharmaceutical secondary standard

InChI

1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H

InChI key

BEEDODBODQVSIM-UHFFFAOYSA-N

SMILES string

Cl.Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. O0290000
traceable to USP 1486004

API family

oxymetazoline

CofA

current certificate can be downloaded

packaging

pkg of 10 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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相关类别

Biochem/physiol Actions

盐酸羟甲唑啉是一种部分 α2A-肾上腺素受体激动剂；5-HT1A、5-HT1B 和 5-HT1D 血清素受体的激动剂。它是 5-HT1C 血清素受体的混合激动剂-拮抗剂。

Application

Oxymetazoline hydrochloride may be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations using spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Oxymetazoline hydrochloride belongs to the category of non-selective adrenergic drugs commonly used as eye and nose drops.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAB5024 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Aquatic Chronic 3 - Eye Dam. 1

存储类别

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

法规信息

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分析证书(COA)

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Spectrophotometric determination of oxymetazoline hydrochloride based on the oxidation reactions
Al-Sabha NT and Rasheed AB
Jordan Journal of Chemistry, 146(605), 1-9 (2011)

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