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Merck
CN

PHR1613

L-甲状腺素

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

3,3′,5,5″-四碘代-L-甲状腺原氨酸, 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸, T4

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关于此项目

线性分子式:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
化学文摘社编号:
51-48-9
分子量:
776.87
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823509
EC Number:
200-101-1
Beilstein/REAXYS Number:
2228515
MDL number:
MFCD00002595

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产品名称

L-甲状腺素, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. L0570000
traceable to USP 1365000

API family

levothyroxine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

223 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... THRA(7067), THRB(7068)

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相关类别

Biochem/physiol Actions

L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Levothyroxine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations and bulk dosage forms and oral liquid formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Levothyroxine is a thyroid hormone that is responsible for the physiological actions such as growth, cardiac functionality, and regulation of carbohydrates, lipid, and protein metabolisms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC1514 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H372

Hazard Classifications

STOT RE 1

target_organs

Thyroid,Cardio-vascular system,Kidney

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Determination of liothyronine and levothyroxine in thyroid preparations by liquid chromatography
Richheimer SL and Jensen CB
Journal of Pharmaceutical Sciences, 75(2), 215-217 (1986)
Oral liquid formulation of levothyroxine is stable in breakfast beverages and may improve thyroid patient compliance
Bernareggi A, et al.
Pharmaceutics, 5(4), 621-633 (2013)
The separation and determination of liothyronine and levothyroxine in tablets by reversed-phase high performance liquid chromatography
Smith DJ, et al.
Journal of Chromatographic Science, 19(2), 72-78 (1981)

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