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Merck
CN

PHR1619

二丙酸倍氯米松

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

二丙酸倍氯米松, 9-氯-11β,17,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮-17,21-二丙酸酯

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关于此项目

经验公式（希尔记法）:
C28H37ClO7
化学文摘社编号:
5534-09-8
分子量:
521.04
NACRES:
NA.24
PubChem Substance ID:
329823513
UNSPSC Code:
41116107
EC Number:
226-886-0
MDL number:
MFCD00135613

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产品名称

二丙酸倍氯米松, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

InChI key

KUVIULQEHSCUHY-XYWKZLDCSA-N

SMILES string

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. B0305000
traceable to USP 1048506

API family

beclometasone

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... NR3C1(2908)

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相关类别

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Beclomethasone Dipropionate may be used as a pharmaceutical secondary reference standard for the determination of the analyte in biological fluids and ear drops formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Beclomethasone Dipropionate is a second generation anti-inflammatory corticosteroid used for the treatment of allergic rhinitis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2965 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Repr. 2 - STOT RE 2

target_organs

Adrenal gland,Immune system,Bone

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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Efficacy and safety of oral beclomethasone dipropionate in ulcerative colitis: a systematic review and meta-analysis
Manguso F, et al.
Testing, 11(11), e0166455-e0166455 (2016)
Simultaneous determination of beclomethasone, beclomethasone monopropionate and beclomethasone dipropionate in biological fluids using a particle beam interface for combining liquid chromatography with negative-ion chemical ionization mass spectrometry
Girault J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 564(1), 43-53 (1991)
Efficacy and safety of beclomethasone dipropionate nasal aerosol in children with perennial allergic rhinitis
Berger WE, et al.
Annals of Allergy, Asthma & Immunology, 115(2), 130-136 (2015)
Determination of beclomethasone dipropionate, clotrimazole, chloramphenicol and lidocaine in pharmaceutical formulations using a novel RP-HPLC method
Reddy MU, et al.
International Journal of Pharma and Bio Sciences, 2(1), 453-462 (2011)
Determination of beclomethasone dipropionate, clotrimazole, chloramphenicol and lidocaine in pharmaceutical formulations using a novel RP-HPLC method
Reddy MU, et al.
International Journal of Pharmacy and Biological Sciences, 2(1), 453-462 (2011)

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