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PHR1619

二丙酸倍氯米松

Name: 二丙酸倍氯米松
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

二丙酸倍氯米松, 9-氯-11β,17,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮-17,21-二丙酸酯

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关于此项目

经验公式（希尔记法）:

C₂₈H₃₇ClO₇

化学文摘社编号:

5534-09-8

分子量:

521.04

NACRES:

NA.24

PubChem Substance ID:

329823513

UNSPSC Code:

41116107

EC Number:

226-886-0

MDL number:

MFCD00135613

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. B0305000, traceable to USP 1048506

API family

beclometasone

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C

InChI

1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

InChI key

KUVIULQEHSCUHY-XYWKZLDCSA-N

Gene Information

human ... NR3C1(2908)

说明

General description

Beclomethasone Dipropionate is a second generation anti-inflammatory corticosteroid used for the treatment of allergic rhinitis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Beclomethasone Dipropionate may be used as a pharmaceutical secondary reference standard for the determination of the analyte in biological fluids and ear drops formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC2965 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS08

signalword

Warning

hcodes

H361fd,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2 - STOT RE 2

target_organs

Adrenal gland,Immune system,Bone

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Efficacy and safety of oral beclomethasone dipropionate in ulcerative colitis: a systematic review and meta-analysis

Manguso F, et al.

Testing, 11(11), e0166455-e0166455 (2016)

Simultaneous determination of beclomethasone, beclomethasone monopropionate and beclomethasone dipropionate in biological fluids using a particle beam interface for combining liquid chromatography with negative-ion chemical ionization mass spectrometry

Girault J, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 564(1), 43-53 (1991)

Efficacy and safety of beclomethasone dipropionate nasal aerosol in children with perennial allergic rhinitis

Berger WE, et al.

Annals of Allergy, Asthma & Immunology, 115(2), 130-136 (2015)

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全球贸易项目编号

货号	GTIN
PHR1619-1G	04061835238071