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Merck
CN

PHR1634

Supelco

依西美坦

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Exemestane, 6-Methyleneandrosta-1,4-diene-3,17-dione

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关于此项目

经验公式（希尔记法）:
C20H24O2
CAS Number:
107868-30-4
分子量:
296.40
MDL编号:
MFCD00866994
UNSPSC代码:
41116107
PubChem化学物质编号:
329823524
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to USP 1269050

API类

exemestane

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

C[C@]12CC[C@H]3[C@@H](CC(=C)C4=CC(=O)C=C[C@]34C)[C@@H]1CCC2=O

InChI

1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1

InChI key

BFYIZQONLCFLEV-DAELLWKTSA-N

基因信息

human ... CYP19A1(1588)

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相关类别

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Exemestane is a steroidal anticancer drug, that belongs to the class of antiestrogens known as aromatase inhibitors. It is commonly used for the treatment of breast cancer.

应用

Exemestane may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Exemestane is a steroidal antiestrogen and irreversible aromatase inhibitor. Exemestane acts as a false substrate for the aromatase enzyme. Exemestane also prevents the conversion of androgens to estrogens and is used to treat estrogen-dependent breast cancer.
Exemestane is a steroidal antiestrogen; aromatase inhibitor.

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3262 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Danger

危险声明

H360,H411

危险分类

Aquatic Chronic 2 - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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访问文档库

Exemestane: a review of its clinical efficacy and safety
Lonning PE
The Breast Journal, 10(3), 198-208 (2001)
Analytical method validation for HPLC assay of oral anticancer drug exemestane
Yavuz B
FABAD Journal of Pharmaceutical Sciences, 32(1), 15-15 (2007)
A novel validated stability-indicating RP-HPLC method for the determination of Exemestane (steroidal aromatase inhibitor)
Mukthinuthalapati MA and Bukkapatnam V
Journal of Bioequivalence & Bioavailability, 7(6), 288-288 (2015)

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