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Merck
CN

PHR1640

氢溴酸西酞普兰

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

氢溴酸西酞普兰 氢溴酸盐, 1-[3-（二甲氨基）丙基]-1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃甲腈 氢溴酸盐

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关于此项目

经验公式（希尔记法）:
C20H21FN2O · HBr
化学文摘社编号:
59729-32-7
分子量:
405.30
NACRES:
NA.24
PubChem Substance ID:
329823528
UNSPSC Code:
41116107
EC Number:
261-890-6
MDL number:
MFCD02101306

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产品名称

氢溴酸西酞普兰, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

WIHMBLDNRMIGDW-UHFFFAOYSA-N

InChI

1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H

SMILES string

Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001008
traceable to USP 1134233

API family

citalopram

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... SLC6A4(6532)

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相关类别

Biochem/physiol Actions

有效的选择性 5-羟色胺摄取抑制剂 (Ki = 5.4 nM)；抗抑郁药

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Citalopram Hydrobromide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7789 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Warning

pictograms

Health hazardExclamation mark
GHS08,GHS07

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3

target_organs

Central nervous system

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Afzal Misrani et al.
Brain research bulletin, 155, 11-18 (2019-11-20)
Curtailment of sleep in modern society leads to a spectrum of neuropsychiatric disorders. However, the molecular mechanisms underlying the effects of sleep deprivation (SD) remain elusive and currently there is no effective therapy to alleviate these effects. Here, we aimed
Development and Application of Spectrophotometric Methods for the Determination of Citalopram Hydrobromide in Dosage Forms.
Raza A
Chemical & Pharmaceutical Bulletin, 54(4), 432-434 (2006)
Spectrophotometric Determination of Citalopram Hydrobromide in Pharmaceuticals.
Narayana B and Veena K
Journal of the Mexican Chemical Society, 54(2), 98-102 (2010)
Quantitative determination of citalopram hydrobromide by spectro- photometry and chemometry in presence of its degradation products and additives in pharmaceutical preparation.
Amer SM, et al.
Analytical Chemistry, 16(2), 53-62 (2016)

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