PHR1682
巴氯芬
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
(±)-巴氯芬, (±)-β-（氨甲基）-4-氯苯丙酸, 巴氯芬片
等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to Ph. Eur. B0200000
traceable to USP 1048200
API类
baclofen
CofA
current certificate can be downloaded
包装
pkg of 1 g
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
ClC1=CC=C(C(CN)CC(O)=O)C=C1
InChI
1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChI key
KPYSYYIEGFHWSV-UHFFFAOYSA-N
基因信息
human ... GABBR1(2550), GABBR2(9568)
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一般描述
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Baclofen is a structural analog of γ-aminobutyric acid (GABA) and an antispastic agent commonly used for the treatment of spasticity as a result of spinal cord or brain injury.
Baclofen is a structural analog of γ-aminobutyric acid (GABA) and an antispastic agent commonly used for the treatment of spasticity as a result of spinal cord or brain injury.
应用
Baclofen may be used as a pharmaceutical secondary reference standard for the determination of the analyte in plasma samples by liquid chromatography tandem mass spectrometry and tablet formulations by UV spectroscopy, respectively.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
生化/生理作用
GABA B 受体激动剂；骨骼肌松弛剂；解痉剂。
分析说明
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
其他说明
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA6298 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Method development and validation of baclofen mouth dissolving tablets by UV spectroscopy
Islam T, et al.
European Journal of Applied Science, 5(1), 7-11 (2013)
Liquid chromatography--tandem mass spectrometry determination of baclofen in various biological samples and application to a pharmacokinetic study
Kim TH, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 938, 43-50 (2013)
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