PHR1685
盐酸非索非那定
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
盐酸非索非那定 盐酸盐, MDL 16455 盐酸盐, 羧酸非索芬那定 盐酸盐, 非索芬那定 盐酸盐
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关于此项目
经验公式（希尔记法）:
C32H39NO4 · HCl
化学文摘社编号:
分子量:
538.12
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H
SMILES string
Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4
InChI key
RRJFVPUCXDGFJB-UHFFFAOYSA-N
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0000789, traceable to USP 1270377
API family
fexofenadine
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... HRH1(3269)
General description
Fexofenadine HCl belongs to the class of drugs known as antihistamines. It acts by selective blockade of H1-receptors and is generally used in the treatment of seasonal allergic rhinitis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Fexofenadine HCl may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulation by spectrophotometry and high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
非索非那定是一种非镇静性 H1 组胺受体拮抗剂。
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB9160 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria
Harold SN, et al.
Annals of Allergy, Asthma & Immunology, 84(5), 517-522 (2000)
RP-HPLC method for the quantitative determination of fexofenadine hydrochloride in coated tablets and human serum
Arayne MS, et al.
Medicinal Chemistry Research, 20(1), 55-61 (2011)
Spectrophotometric and high performance liquid chromatographic determination of fexofenadine hydrochloride in pharmaceutical formulations
Kozan I, et al
Turkish Journal of Pharmaceutical Sciences, 5(3), 175-189 (2008)
Development and validation of a rapid RP-HPLC method for the determination of cetirizine or fexofenadine with pseudoephedrine in binary pharmaceutical dosage forms
Karakus S, et al.
Journal of Pharmaceutical and Biomedical Analysis, 46(2), 295-302 (2008)
Fexofenadine Hydrochloride
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 34(3)(1), 1828-1828 (2019)
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