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Merck
CN

PHR1685

Supelco

盐酸非索非那定

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

盐酸非索非那定 盐酸盐, MDL 16455 盐酸盐, 羧酸非索芬那定 盐酸盐, 非索芬那定 盐酸盐

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关于此项目

经验公式（希尔记法）:
C32H39NO4 · HCl
化学文摘社编号:
153439-40-8
分子量:
538.12
MDL编号:
MFCD00865710
UNSPSC代码:
41116107
PubChem化学物质编号:
329823555
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. Y0000789
traceable to USP 1270377

API类

fexofenadine

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4

InChI

1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H

InChI key

RRJFVPUCXDGFJB-UHFFFAOYSA-N

基因信息

human ... HRH1(3269)

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相关类别

一般描述

Fexofenadine HCl belongs to the class of drugs known as antihistamines. It acts by selective blockade of H1-receptors and is generally used in the treatment of seasonal allergic rhinitis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Fexofenadine HCl may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulation by spectrophotometry and high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

非索非那定是一种非镇静性 H1 组胺受体拮抗剂。

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB9160 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria
Harold SN, et al.
Annals of Allergy, Asthma & Immunology, 84(5), 517-522 (2000)
Development and validation of a rapid RP-HPLC method for the determination of cetirizine or fexofenadine with pseudoephedrine in binary pharmaceutical dosage forms
Karakus S, et al.
Journal of Pharmaceutical and Biomedical Analysis, 46(2), 295-302 (2008)
RP-HPLC method for the quantitative determination of fexofenadine hydrochloride in coated tablets and human serum
Arayne MS, et al.
Medicinal Chemistry Research, 20(1), 55-61 (2011)
Spectrophotometric and high performance liquid chromatographic determination of fexofenadine hydrochloride in pharmaceutical formulations
Kozan I, et al
Turkish Journal of Pharmaceutical Sciences, 5(3), 175-189 (2008)
Fexofenadine Hydrochloride
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 34(3)(1), 1828-1828 (2019)

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