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Merck
CN

PHR1700

利巴韦林

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

利巴韦林, 1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺

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关于此项目

经验公式（希尔记法）:
C8H12N4O5
化学文摘社编号:
36791-04-5
分子量:
244.20
NACRES:
NA.24
PubChem Substance ID:
329823563
UNSPSC Code:
41116107
MDL number:
MFCD00058564

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产品名称

利巴韦林, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

IWUCXVSUMQZMFG-AFCXAGJDSA-N

SMILES string

NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

InChI

1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur.
traceable to USP 1602706

API family

ribavirin

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... IMPDH1(3614)

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相关类别

Biochem/physiol Actions

用于抵御多种人类病毒感染的抗病毒剂，特别是慢性肝炎C、HIV 和腺病毒。其代谢产物利巴韦林 5′-磷酸，是肌苷一磷酸 (IMP) 脱氢酶的抑制剂。
用于抵御多种人类病毒感染的抗病毒剂，特别是慢性肝炎C、HIV 和腺病毒。其代谢产物利巴韦林 5′-磷酸，是肌苷一磷酸 (IMP) 脱氢酶的抑制剂，但也有实验证据支持许多其他作用机制。

General description

嘌呤核苷酸生物合成中咪唑核苷酸中间体的类似物。
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
Ribavirin is a synthetic guanosine analog, effective against respiratory syncytial virus, several hemorrhagic fever viruses and human immuno deficiency virus.Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Ribavirin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high-pressure liquid chromatographic method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA6966 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Muta. 2 - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Intravenous ribavirin and hyperammonemia in an immunocompromised patient infected with adenovirus.
Bertrand P, et al.
Pharmacotherapy, 20(10), 1216-1220 (2000)
Stability-Indicating HPLC-DAD Determination of Ribavirin in Capsules and Plasma.
Haggag RS, et al.
Journal of Chromatographic Science, 52(6), 493-500 (2013)

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