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PHR1721

特拉唑嗪

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

特拉唑嗪 盐酸盐 二水合物

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经验公式（希尔记法）:
C19H25N5O4 · HCl · 2H2O
化学文摘社编号:
70024-40-7
分子量:
459.92
NACRES:
NA.24
PubChem Substance ID:
329823574
UNSPSC Code:
41116107
MDL number:
MFCD00941408

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InChI key

NZMOFYDMGFQZLS-UHFFFAOYSA-N

SMILES string

O.O.Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4

InChI

1S/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000621, traceable to USP 1643452

API family

terazosin

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Terazosin Hydrochloride belongs to the class of a1-adrenergic blockers, widely used for the treatment of benign prostatic hyperplasia (BPH) affecting the urogenital tract in men.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

It may be used as drug standard stock solution for determination of terazosin hydrochloride dihydrate using potentiometric and fluorimetric techniques.
Terazosin Hydrochloride may be used as a drug standard stock solution for the determination of terazosin hydrochloride dihydrate using potentiometric and fluorimetric techniques.
Terazosin Hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance thin layer chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7395 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Validated HPTLC method for the simultaneous determination of alfuzosin, terazosin, prazosin, doxazosin and finasteride in pharmaceutical formulations
Belal.ST, et al.
Analytical Chemistry Research, 1, 23-31 (2014)
Potentiometric and fluorimetric methods for the determination of terazosin HCl in drug substance and dosage forms.
Ismail, Nahla S., and Taghreed A. Mohamed.
International Journal of Electrochemical Science, 9, 7394-7394 (2014)
Terazosin potentiometric sensor for quantitative analysis of terazosin hydrochloride in pharmaceutical formulation based on computational study.
Hosseini, Morteza, Ensieh Nasli-Esfahani, and Parviz Norouzi.
International Journal of Electrochemical Science, 5, 200-214 (2010)

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