PHR1751
盐酸胍法辛
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
Guanfacine hydrochloride, N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide
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经验公式（希尔记法）:
C9H9Cl2N3O · HCl
化学文摘社编号:
分子量:
282.55
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
249-443-3
MDL number:
InChI key
DGFYECXYGUIODH-UHFFFAOYSA-N
InChI
1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
SMILES string
Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to USP 1302101
API family
guanfacine
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
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General description
Guanfacine hydrochloride, is a selective α-adrenergic receptor agonist, that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Guanfacine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry and high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
α-2 noradrenergic receptor agonist.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3708 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Spectrophotometric analysis of some guanidino drugs by acid-dye and charge-transfer complexation methods
Wahbi AM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 11(8), 639- 645 (1993)
Guanfacine hydrochloride
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 45(3), 2133-2133 (2018)
Guanfacine and secondary mania in children
Horrigan JP and Barnhill LJ
Journal of Affective Disorders, 54(3), 309- 314 (1999)
L A Cornish
Clinical pharmacy, 7(3), 187-197 (1988-03-01)
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of guanfacine hydrochloride are reviewed. Guanfacine lowers blood pressure by activating CNS alpha adrenoreceptors, which results in sympathetic outflow leading to reduced vascular tone. However, initial hypotensive response to guanfacine may
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