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Merck
CN

PHR1801

米诺环素 盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Minocycline hydrochloride

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关于此项目

经验公式（希尔记法）:
C23H27N3O7 · HCl
化学文摘社编号:
13614-98-7
分子量:
493.94
UNSPSC Code:
41116107
NACRES:
NA.24
EC Number:
237-099-7
MDL number:
MFCD00083669

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产品名称

米诺环素 盐酸盐, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

GLMUAFMGXXHGLU-VQAITOIOSA-N

InChI

1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1

SMILES string

Cl.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001930

API family

minocycline

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Minocycline Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0276 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Separation differences among phenyl hydride, UDC cholesterol, and bidentate C8 stationary phases for stability indicating methods of tetracyclines.
Young JE, et al.
Journal of Liquid Chromatography and Related Technologies, 36(7), 926-942 (2013)
Supercritical antisolvent micronization of minocycline hydrochloride.
Cardoso MAT, et al.
Journal of Supercritical Fluids, 44(2), 238-244 (2008)

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