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Merck
CN

PHR1909

Supelco

阿替洛尔

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

阿替洛尔, (±)-4-[2-羟基-3-[(1-甲基乙基)氨基] 丙氧基] 苯乙酰胺, 4-[2′-羟基-3′-(异丙胺基)丙氧基] 苯乙酰胺

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关于此项目

经验公式(希尔记法):
C14H22N2O3
化学文摘社编号:
分子量:
266.34
EC 号:
MDL编号:
UNSPSC代码:
41116107
NACRES:
NA.24
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等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to Ph. Eur. A1340000
traceable to USP 1044403

API类

atenolol

表单

powder

CofA

current certificate can be downloaded

包装

pkg of 500 mg

应用

pharmaceutical

储存温度

2-30°C

SMILES字符串

CC(C)NCC(O)COc1ccc(CC(N)=O)cc1

InChI

1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)

InChI key

METKIMKYRPQLGS-UHFFFAOYSA-N

基因信息

human ... ADRB1(153)

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一般描述

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Atenolol is a beta-1 blocker used in the treatment of various cardiovascular diseases.

应用

This pharmaceutical secondary standard can also be used as follows:

  • Simultaneous analysis of atenolol and nifedipine using magnesium oxide-nanoplatelets (MgO-NPLs) modified screen-printed electrodes (SPEs) by differential pulse voltammetry (DPV) from pharmaceutical dosage forms and urine samples
  • Voltammetric determination of amlodipine besylate and atenolol in their combined pharmaceutical formulations using a cathodically pretreated-boron doped diamond electrode (CP-BDDE)
  • Spectrofluorimetric determination of atenolol using gold nanoparticles (AuNPs) based photo probes in commercial tablets
  • Amperometric estimation of atenolol using bismuth vanadate-bismuth(III) oxide (BiVO4–Bi2O) composite electrode in pharmaceutical formulations and human urine samples
  • Development of a reversed phase-high performance liquid chromatography (RP-HPLC) method coupled to a photodiode array detector (PDA) for the quantitative analysis of atenolol and trimetazidine in human urine and pharmaceutical tablets

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAC0712 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品
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分析证书(COA)

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Simultaneous voltammetric determination of antihypertensive drugs nifedipine and atenolol utilizing MgO nanoplatelet modified screen-printed electrodes in pharmaceuticals and human fluids
Khairy M, et al.
Sensors and Actuators B, Chemical, 252, 1045-1054 (2017)
BiVO4-Bi2O3/ITO electrodes prepared by layer-by-layer: application in the determination of atenolol in pharmaceutical formulations and urine
Afonso R, et al.
Journal of Electroanalytical Chemistry, 765, 30-36 (2016)
Simultaneous voltammetric determination of antihypertensive drugs amlodipine and atenolol in pharmaceuticals using a cathodically pretreated boron-doped diamond electrode
Moraes JT, et al.
Journal of the Brazilian Chemical Society, 27, 1264-1272 (2016)

商品

TLC plates, with silica gel, gypsum as binder, International Pharmacopoeia compliant, for identification of Atenolol and Chlorthalidone in tablets.

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