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Merck
CN

PHR2363

Supelco

维生素K2-（MK-7）

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

（all-E)–2-（3,7,11,15,19,23,27-七甲基-2,6,10,14,18,22,26-十八碳庚烯基）-3-甲基-1,4-萘二酮

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关于此项目

经验公式（希尔记法）:
C46H64O2
化学文摘社编号:
2124-57-4
分子量:
649.00
UNSPSC代码:
41116107
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to USP 1381119

API类

menaquinone

表单

solid

CofA

current certificate can be downloaded

包装

pkg of 3x75 mg

应用

pharmaceutical small molecule

储存温度

-10 to -25°C

SMILES字符串

O=C1c2c(cccc2)C(=O)C(=C1C\C=C(\CC\C=C(\CC\C=C(\CC\C=C(\CC\C=C(\CC\C=C(\CCC=C(C)C)/C)/C)/C)/C)/C)/C)C

InChI

1S/C46H64O2/c1-34(2)18-12-19-35(3)20-13-21-36(4)22-14-23-37(5)24-15-25-38(6)26-16-27-39(7)28-17-29-40(8)32-33-42-41(9)45(47)43-30-10-11-31-44(43)46(42)48/h10-11,18,20,22,24,26,28,30-32H,12-17,19,21,23,25,27,29,33H2,1-9H3/b35-20+,36-22+,37-24+,38-26+,39-28+,40-32+

InChI key

RAKQPZMEYJZGPI-LJWNYQGCSA-N

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相关类别

一般描述

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Menaquinone -7 is a naphthoquinone derivative and one of the most active sub-type of vitamin K2, with 7 referring to the number of isoprene units in its structure. It is naturally found in fermented dairy products and is considered a nutrient, thereby being found as a component of various nutritional supplements.

应用

This pharmaceutical secondary standard can also be used as follows:
  • Ultra high-performance liquid chromatography (UHPLC) based determination of menaquinone-7 and vitamin D3 in their combined tablet formulation
  • Development of a thin-layer chromatographic-densitometric technique for the quantitative analysis of vitamins K and D3 in pharmaceutical tablet formulations and dietary supplements
  • Simultaneous determination of vitamin D3 and K2 (Menaquinone-4 and Menaquinone-7) in dietary supplements by ultra-high-pressure liquid chromatography (UHPLC)
  • Impurity profiling of menaquinone-7 in its active pharmaceutical ingredient (API) samples using HPLC coupled to UV detector
  • Analysis of menaquinone-4 and menaquinone-7 by HPLC in combination with tandem mass spectrometry (MS/MS) in human milk samples

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAC4030 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Liquid chromatography-tandem mass spectrometry method for the determination of vitamin K homologues in human milk after overnight cold saponification
Gentili A, et al.
Journal of food composition and analysis, 47, 21-30 (2016)
Determination of vitamins K1, K2 MK-4, MK-7, MK-9 and D3 in pharmaceutical products and dietary supplements by TLC-densitometry
Hubicka U, et al.
Processes, 8, 870-870 (2020)
Łukasz Jedynak et al.
Journal of pharmaceutical and biomedical analysis, 135, 116-125 (2016-12-27)
An HPLC method with UV detection and separation with the use of a C30 reversed phase analytical column for the determination of chemical purity and assay of menaquinone-7 (MK7) in one chromatographic run was developed. The method is superior to

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