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文件

PHR2379

Supelco

Safinamide Mesylate

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
Safinamide mesylate salt, (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;
经验公式（希尔记法）:
C17H19FN2O2 · xCH4O3S
CAS号:
202825-46-5
分子量:
302.34 (free base basis)
MDL编号:
MFCD15145475

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

API family

safinamide

形式

powder

CofA

current certificate can be downloaded

包装

pkg of 50 mg

储存温度

2-8°C

SMILES string

CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O

InChI

1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1

InChI key

YKOCHIUQOBQIAC-YDALLXLXSA-N

Gene Information

human ... MAOB(4129)

相关类别

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC4350 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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示例

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包装规格/数量

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商品

HPLC Assay and Impurity Profiling Methods for Safinamide and Safinamide Related Impurities

A sensitive and reproducible HPLC-DAD method for the purity analysis of safinamide and its related impurities using an Ascentis® Express C8 column (150 x 4.6 mm, 5 μm), meeting the system suitability criteria.

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