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Merck
CN

PHR2379

Supelco

Safinamide Mesylate

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Safinamide mesylate salt, (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;

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关于此项目

经验公式（希尔记法）:
C17H19FN2O2 · xCH4O3S
CAS Number:
202825-46-5
分子量:
302.34 (free base basis)
MDL编号:
MFCD15145475
UNSPSC代码:
41116107
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

API类

safinamide

表单

powder

CofA

current certificate can be downloaded

包装

pkg of 50 mg

应用

pharmaceutical small molecule

储存温度

2-8°C

SMILES字符串

CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O

InChI

1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1

InChI key

YKOCHIUQOBQIAC-YDALLXLXSA-N

基因信息

human ... MAOB(4129)

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相关类别

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.
Safinamide is a sodium and calcium channel blocker that is also a selective and reversible inhibitor of monoamine oxidase type B (MAO-B); anticonvulsant

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC4350 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险声明

H302,H319,H361d

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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商品

Safinamide Impurity Profiling by HPLC Assay Methods

HPLC-DAD method on Ascentis® Express C8 column analyzes safinamide purity and related impurities meeting system suitability criteria.

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