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Merck
CN

PHR3040

8-甲氧基补骨脂素

pharmaceutical secondary standard, certified reference material

别名:

8-MOP, 9-甲氧基呋喃 [3,2- g ] 苯并吡喃-7-酮, 甲氧沙林, 花椒毒内酯, 花椒毒素

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经验公式(希尔记法):
C12H8O4
化学文摘社编号:
分子量:
216.19
NACRES:
NA.24
UNSPSC Code:
41116107
Beilstein/REAXYS Number:
196453
MDL number:
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SMILES string

COc1c2OC(=O)C=Cc2cc3ccoc13

InChI key

QXKHYNVANLEOEG-UHFFFAOYSA-N

InChI

1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1417001

API family

methoxsalen

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

mp

148-150 °C (lit.)

application(s)

pharmaceutical

storage temp.

2-30°C

Quality Level

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

8-甲氧基补骨脂素 (8-MOP) 加 A 波紫外线 (UVA) 辐射可诱导单加合物形成和 DNA 链间交联,因此可用于研究 DNA 修复和重组机制。培养的正常人黑素细胞经 8-甲氧基补骨脂素处理和 A 波紫外线 (UVA) 照射后形成 8-甲氧基补骨脂素-磷脂光加成产物,经二酰甘油取代后可在无细胞体系中激活蛋白激酶 C。8-MOP 是纯化重组细胞色素 P450 的灭活剂。它还可以通过抑制 [Ca2+] 的升高,而抑制从 P 物质激活的大鼠腹膜肥大细胞的 P 物质诱导型组胺释放。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Muta. 2 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

高风险级别生物产品--毒素类产品
此项目有

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