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安全信息

PHR8659

Teriparatide

new

certified reference material, pharmaceutical secondary standard

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别名:
Parathyroid Hormone Fragment 1-34 human, PTH 1-34, Parathormone (1-34)
经验公式（希尔记法）:
C181H291N55O51S2
CAS号:
52232-67-4
分子量:
4117.72
MDL编号:
MFCD00149013

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to EP Y0001916
traceable to USP 1643962

API family

teriparatide

包装

pkg of 1MG

application(s)

pharmaceutical

InChI

1S/C181H291N55O51S2.C2H4O2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97;1-2(3)4/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199);1H3,(H,3,4)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-;/m0./s1

InChI key

BUUKFBVDKSFMHN-LKMAISLMSA-N

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相关类别

Amino Acid Sequence

Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe

一般描述

Teriparatide, a pharmaceutical secondary standard, is a recombinant fragment of human parathyroid hormone. The therapeutic is a potent osteoanabolic agent. It consists of the first 34 aminoacids of the hormone′s N-terminal region. Teriparatide is an analog of parathyroid hormone. It binds to the parathyroid hormone (PTH) type 1 receptor using its N-terminal portion.

应用

The teriparatide pharmaceutical secondary standard is a certified reference material (CRM) that includes a comprehensive Certificate of Analysis (COA). This new product also includes the added value of traceability to the current USP and EP primary reference standard batch. Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

生化/生理作用

Teriparatide exhibits similar effects to endogenous parathyroid hormone (PTH), regulating calcium and phosphate levels by increasing serum calcium and decreasing serum phosphate. These effects primarily occur through the well-established effects of PTH on the kidneys and bone. Teriparatide acts as an effective agent in managing osteoporosis. In addition to its therapeutic benefits, teriparatide also carries a theoretical risk of osteosarcoma as a potential side effect.

其他说明

This secondary biopharma certified reference material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. These secondary standards offer multi-traceability to the USP, EP, and BP primary standards, where they are available.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

分析证书(COA)

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示例

T1503
货号
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25G
包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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索取COA

Teriparatide
Vall H and Parmar M.
StatPearls [Internet] (2023)

商品

Teriparatide Peptide Mapping Analysis by Liquid Chromatography-UV-Mass Spectrometry

This application note describes a step-by-step LC-UV-MS workflow for teriparatide peptide mapping, that includes enzymatic digestion, separation conditions, and their high resolution QTOF mass spectrometer based identification.

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