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Merck
CN

R0300000

醋酸维生素 A

European Pharmacopoeia (EP) Reference Standard

别名:

视黄醇乙酸酯, 维生素 A 醋酸酯, 醋酸维生素 A

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关于此项目

经验公式(希尔记法):
C22H32O2
化学文摘社编号:
分子量:
328.49
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1915439
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InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

retinyl compounds

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

mp

57-58 °C

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

General description

本品根据现行药典要求提供和指定。所有为支持本产品而提供的信息,包括SDS和任何产品信息小册子,均根据现行药典制定和发布。更多信息和支持请访问药典颁发机构网站。

视黄醇乙酸酯属于视黄醇类,与维生素A在化学上相关。视黄醇用于通过口服和局部给药治疗痤疮和牛皮癣。

Application

本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。

Packaging

本品按照现行药典要求提供。有关当前单位数量,请见EDQM 参考目录

Other Notes

可能适用相应的销售限制。

pictograms

Health hazard

signalword

Danger

Hazard Classifications

Aquatic Chronic 4 - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Simultaneous determination of retinol acetate, retinol palmitate, cholecalciferol, α-tocopherol acetate and alphacalcidol in capsules by non-aqueous reversed-phase HPLC and column backflushing
Wielinski S and Olszanowski A
Chromatographia, 50(1-2), 109-112 (1999)
Guangwen Tang et al.
The American journal of clinical nutrition, 89(6), 1776-1783 (2009-04-17)
Genetically engineered "Golden Rice" contains up to 35 microg beta-carotene per gram of rice. It is important to determine the vitamin A equivalency of Golden Rice beta-carotene to project the potential effect of this biofortified grain in rice-consuming populations that
Emmanuel K Aklamati et al.
The Journal of nutrition, 140(9), 1588-1594 (2010-07-28)
A survey indicated that high-dose vitamin A (HD-VA) supplements had no apparent effect on vitamin A (VA) status, assessed by serum retinol concentrations, of Zambian children lt 5 y of age. To explore possible reasons for the lack of response
Avash J Singh et al.
Pediatric research, 67(6), 619-623 (2010-03-11)
Chronic lung disease (CLD) is a major cause of long-term morbidity in extremely LBW infants with respiratory distress syndrome. Parenteral vitamin A administration decreases the risk of CLD. We tested the hypothesis that intratracheal vitamin A administration with surfactant is
Sunatda Arayachukeat et al.
International journal of pharmaceutics, 404(1-2), 281-288 (2010-11-26)
Retinyl acetate (RA) loaded polymeric nanoparticle (NP) carriers were prepared using two different single polymers, ethyl cellulose (EC) and poly (ethylene glycol)-4-methoxycinnamoylphthaloylchitosan (PCPLC). The stability of RA to aqueous solution and UVA light was significantly improved when encapsulated with PCPLC

实验方案

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.

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