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文件

R0300000

醋酸维生素 A

Name: 醋酸维生素 A
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

视黄醇乙酸酯, 维生素 A 醋酸酯, 醋酸维生素 A

经验公式（希尔记法）:

C₂₂H₃₂O₂

CAS号:

127-47-9

分子量:

328.49

Beilstein:

1915439

MDL编号:

MFCD00019413

PubChem化学物质编号:

329823984

NACRES:

NA.24

生物来源

synthetic

等级

pharmaceutical primary standard

Agency

API family

retinyl compounds

形式

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

57-58 °C

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

−20°C

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

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一般描述

本品根据现行药典要求提供和指定。所有为支持本产品而提供的信息，包括SDS和任何产品信息小册子，均根据现行药典制定和发布。如需进一步的信息和支持，请访问现行药典网站。视黄醇乙酸酯属于视黄醇类，与维生素A在化学上相关。视黄醇用于通过口服和局部给药治疗痤疮和牛皮癣。

应用

本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。

包装

本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。

其他说明

可能适用相应的销售限制。

警示用语：

Danger

危险声明

H360D - H413

预防措施声明

P202 - P273 - P280 - P308 + P313 - P405 - P501

危险分类

Aquatic Chronic 4 - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Simultaneous determination of retinol acetate, retinol palmitate, cholecalciferol, α-tocopherol acetate and alphacalcidol in capsules by non-aqueous reversed-phase HPLC and column backflushing

Wielinski S and Olszanowski A

Chromatographia, 50(1-2), 109-112 (1999)

Nanoscale domains with nematic order in supercooled vitamin-A acetate: molecular dynamics studies.

Z Wojnarowska et al.

Physical review. E, Statistical, nonlinear, and soft matter physics, 83(5 Pt 1), 051502-051502 (2011-07-07)

Vitamin-A acetate is one of the most versatile vitamins. It is applied in medicine because of its antioxidative properties, in tumor therapy because of its cytostatic activity, and in cosmetics because of its nutritional additives. Herein, using broadband dielectric spectroscopy

A randomized controlled trial to assess the impact of dietary energy sources, feed supplements, and the presence of super-shedders on the detection of Escherichia coli O157:H7 in feedlot cattle using different diagnostic procedures.

Natalia Cernicchiaro et al.

Foodborne pathogens and disease, 7(9), 1071-1081 (2010-05-27)

Alteration of the gastro-intestinal tract through manipulation of cattle diets has been proposed as a preharvest control measure to reduce fecal shedding of Escherichia coli O157:H7. The objective of this study was to examine the effects of the energy source's

Retinyl acetate-loaded nanoparticles: dermal penetration and release of the retinyl acetate.

Sunatda Arayachukeat et al.

International journal of pharmaceutics, 404(1-2), 281-288 (2010-11-26)

Retinyl acetate (RA) loaded polymeric nanoparticle (NP) carriers were prepared using two different single polymers, ethyl cellulose (EC) and poly (ethylene glycol)-4-methoxycinnamoylphthaloylchitosan (PCPLC). The stability of RA to aqueous solution and UVA light was significantly improved when encapsulated with PCPLC

Vitamin A is systemically bioavailable after intratracheal administration with surfactant in an animal model of newborn respiratory distress.

Avash J Singh et al.

Pediatric research, 67(6), 619-623 (2010-03-11)

Chronic lung disease (CLD) is a major cause of long-term morbidity in extremely LBW infants with respiratory distress syndrome. Parenteral vitamin A administration decreases the risk of CLD. We tested the hypothesis that intratracheal vitamin A administration with surfactant is

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实验方案

HPLC Analysis of Vitamins, Fat Soluble (A and E), on SUPELCOSIL™ LC-18

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.

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