Merck
CN

S0040000

糖精

European Pharmacopoeia (EP) Reference Standard

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别名:
2,3-二羟基-1,2-苯并异噻唑基-3-酮-1,1-二氧化物, 2-磺基苯甲酸亚胺, 邻磺酰苯酰亚胺
Empirical Formula (Hill Notation):
C7H5NO3S
CAS号:
分子量:
183.18
Beilstein:
6888
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

pharmaceutical primary standard

API family

saccharin

manufacturer/tradename

EDQM

mp

226-229 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

InChI key

CVHZOJJKTDOEJC-UHFFFAOYSA-N

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此商品
411311607007PHR1341
Saccharin European Pharmacopoeia (EP) Reference Standard

S0040000

糖精

Saccharin United States Pharmacopeia (USP) Reference Standard

USP

1607007

糖精

Saccharin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1341

糖精钠

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

USP

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

food and beverages
pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

saccharin

API family

-

API family

saccharin

API family

saccharin

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Saccharin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

哺乳动物的甜促味剂。有人提出,果蝇具有葡萄糖特异性甘油味觉受体结合位点。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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R L Anderson
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(7), 637-644 (1988-07-01)
An hypothesis is presented of a mechanism for the sodium saccharin (NaS)-associated tumorigenesis of the urinary bladder that occurs in male rats. The ingestion of high doses of NaS is associated with increased urine volume and bladder mass. In rats
D L Arnold et al.
Toxicology, 27(3-4), 179-256 (1983-07-01)
Saccharin, first synthesized in 1879, eventually became popular as an inexpensive substitute for sugar, particularly as a non-caloric sweetner. The dispute concerning the safety of saccharin for human consumption is almost as old as saccharin itself. In this article, the
Marilyn E Carroll et al.
Behavioural pharmacology, 19(5-6), 435-460 (2008-08-12)
A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature. The proposed genetic contribution to this relationship has been based on evidence
A G Renwick
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 23(4-5), 429-435 (1985-04-01)
Recent studies on saccharin in animals and man have allowed a detailed understanding of its fate in the body. Saccharin is slowly absorbed from the gut but rapidly eliminated in the urine, largely by renal tubular secretion. Saccharin does not
L B Ellwein et al.
Critical reviews in toxicology, 20(5), 311-326 (1990-01-01)
Almost from its discovery in 1879, the use of saccharin as an artificial, non-nutritive sweetener has been the center of several controversies regarding potential toxic effects, most recently focusing on the urinary bladder carcinogenicity of sodium saccharin in rats when

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