产品名称
甲苯磺丁脲, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
SMILES string
CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
InChI key
JLRGJRBPOGGCBT-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
tolbutamide
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
human ... ABCC8(6833), KCNJ11(3767)
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Ning Wang et al.
ACS nano, 9(3), 3159-3168 (2015-03-12)
Cytochromes P450 (CYPs) enzymes are involved in catalyzing the metabolism of various endogenous and exogenous compounds. A rapid analysis of drug metabolism reactions by CYPs is required because they can metabolize 95% of current drugs in drug development and effective
Paulette B Goforth et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11405-11415 (2014-08-22)
The adipocyte-derived hormone leptin modulates neural systems appropriately for the status of body energy stores. Leptin inhibits lateral hypothalamic area (LHA) orexin (OX; also known as hypocretin)-producing neurons, which control feeding, activity, and energy expenditure, among other parameters. Our previous
Arian F Baquero et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 9982-9994 (2014-07-25)
Leptin is well known for its role in the regulation of energy homeostasis in adults, a mechanism that at least partially results from the inhibition of the activity of NPY/AgRP/GABA neurons (NAG) in the arcuate nucleus of the hypothalamus (ARH).
Cheng-Lung Hsu et al.
Oncotarget, 5(8), 2187-2197 (2014-04-20)
Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence the AR or its downstream signaling.
Zhiping Lin et al.
Die Pharmazie, 69(7), 537-541 (2014-07-31)
To investigate the influence of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 in rats in vivo. Scutellarin and saline were intravenously administered to male Wistar rats via the caudal vein for 7 days consecutively. On the 8th
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