InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
SMILES string
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
InChI key
SHGAZHPCJJPHSC-YCNIQYBTSA-N
biological source
synthetic
grade
pharmaceutical primary standard
agency
EP
API family
tretinoin
form
solid
manufacturer/tradename
EDQM
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
mp
180-181 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
human ... RARA(5914), RARB(5915), RARG(5916)
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General description
本品根据现行药典要求提供和指定。所有为支持本产品而提供的信息，包括SDS和任何产品信息小册子，均根据现行药典制定和发布。更多信息和支持请访问药典颁发机构网站。
维甲酸是一种用于治疗各种皮肤病的药物，如光损伤皮肤、痤疮等。它用作抗衰老产品，也用作白血病的口服药物。
维甲酸是一种用于治疗各种皮肤病的药物，如光损伤皮肤、痤疮等。它用作抗衰老产品，也用作白血病的口服药物。
Application
本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。
Biochem/physiol Actions
全−反式−视黄酸（ATRA）是视黄酸受体（RAR）和视黄醇类 X 受体（RXR）的配体。所结合的RAR和RXR可作为调节正常细胞和恶性细胞的生长和分化的转录因子。细胞色素P450（CYP）可催化ATRA的4-羟基化。视黄酸可使胚胎干细胞成为神经元。
视黄酸受体（RAR）和类视黄醇X受体（RXR）的配体; 引发胚胎干细胞成为神经元。
Packaging
本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。
Other Notes
可能适用相应的销售限制。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Tretinoin: The Active Retinoid Medication Used for Treatment of Acne Fast and Effectively (2019)
A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations
Tashtoush BM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(3) (2007)
Bogdan Jakiela et al.
American journal of respiratory cell and molecular biology, 51(2), 229-241 (2014-03-05)
Human rhinoviruses (RVs) are a major cause of exacerbations in asthma and other chronic airway diseases. A characteristic feature of asthmatic epithelium is goblet cell metaplasia and mucus hypersecretion. Bronchial epithelium is also an important source of lipid mediators, including
Mathilde Raverdeau et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 2953-2958 (2014-03-25)
Retinoic acid (RA) is produced by a number of cell types, including macrophages and dendritic cells, which express retinal dehydrogenases that convert vitamin A to its main biologically active metabolite, all-trans RA. All-trans RA binds to its nuclear retinoic acid
Enrico Garattini et al.
Cancer treatment reviews, 40(6), 739-749 (2014-02-01)
All-trans retinoic acid (ATRA) is the most important active metabolite of vitamin A controlling segmentation in the developing organism and the homeostasis of various tissues in the adult. ATRA as well as natural and synthetic derivatives, collectively known as retinoids
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