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T2005010

Triflusal impurity B

Name: Triflusal impurity B
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

2-Hydroxy-4-(trifluoromethyl)benzoic acid, 4-(Trifluoromethyl)salicylic acid

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关于此项目

经验公式（希尔记法）:

C₈H₅F₃O₃

化学文摘社编号:

328-90-5

分子量:

206.12

UNSPSC Code:

41116107

NACRES:

NA.24

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属性

grade

pharmaceutical primary standard

API family

triflusal

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(c(cc1)C(=O)O)O

InChI

1S/C8H5F3O3/c9-8(10,11)4-1-2-5(7(13)14)6(12)3-4/h1-3,12H,(H,13,14)

InChI key

XMLFPUBZFSJWCN-UHFFFAOYSA-N

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Triflusal impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Protective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids.

J A González-Correa et al.

Naunyn-Schmiedeberg's archives of pharmacology, 371(1), 81-88 (2004-12-17)

Triflusal is a fluorinated derivative of acetylsalicylic acid (ASA) with demonstrated antithrombotic activity. Recently, evidence for a neuroprotective effect has been obtained. The aim of this study was to compare the neuroprotective effects of the main metabolite of triflusal (2-hydroxy-4-trifluoromethylbenzoic

Pharmacokinetics of triflusal after single and repeated doses in man.

J Ramis et al.

International journal of clinical pharmacology, therapy, and toxicology, 28(8), 344-349 (1990-08-01)

Triflusal pharmacokinetics were evaluated in 8 healthy subjects after a single 300 mg dose and after repeated doses of 300 mg every 8 h and 600 mg every 24 h during 13 days, with the aim of establishing a relationship

4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation.

Y Bayón et al.

British journal of pharmacology, 126(6), 1359-1366 (1999-04-27)

1. The effect of two derivatives of salicylate, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) and 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal), on the activation of NF-kappaB elicited by tumour necrosis factor-alpha (TNF-alpha) on human umbilical vein endothelial cells (HUVEC) was tested. 2. The expression of the

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货号	GTIN
T2005010	04061833801352