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COO原产地证书/COA分析证书

Y0000245

Ketobemidone impurity C

Name: Ketobemidone impurity C
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

1-[4-(3-Hydroxyphenyl)piperidin-4-yl]propan-1-one

经验公式（希尔记法）:

C₁₄H₁₉NO₂

CAS号:

15847-72-0

分子量:

233.31

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

ketobemidone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

InChI

1S/C14H19NO2/c1-2-13(17)14(6-8-15-9-7-14)11-4-3-5-12(16)10-11/h3-5,10,15-16H,2,6-9H2,1H3

InChI key

BJTDPLRIKDSWIS-UHFFFAOYSA-N

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Ketobemidone impurity C EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

Y0000244

Ketobemidone impurity B, European Pharmacopoeia (EP) Reference Standard

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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Simultaneous analysis of five antidepressant drugs using direct injection of biofluids in a capillary restricted-access media-liquid chromatography-tandem mass spectrometry system.

Alvaro J Santos-Neto et al.

Journal of chromatography. A, 1189(1-2), 514-522 (2008-03-22)

Direct analysis, with minimal sample pretreatment, of antidepressant drugs, fluoxetine, imipramine, desipramine, amitriptyline, and nortriptyline in biofluids was developed with a total run time of 8 min. The setup consists of two HPLC pumps, injection valve, capillary RAM-ADS-C18 pre-column and

Simultaneous determination of ketobemidone and its N-demethylated metabolite in patient plasma samples by gas chromatography mass spectrometry with selected ion monitoring.

U Bondesson et al.

Biomedical mass spectrometry, 10(4), 283-286 (1983-04-01)

An analytical procedure has been developed for the simultaneous determination of ketobemidone and its N-demethylated metabolite, norketobemidone. After isolation from plasma and re-extraction to acidic aqueous phase, the two aminophenols were extracted as ions pairs with tetrabutylammonium to dichloromethane, where

Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.

U Yasar et al.

Xenobiotica; the fate of foreign compounds in biological systems, 35(8), 785-796 (2005-11-10)

The role of the major drug-metabolizing cytochrome P450 (CYP) enzymes as well as P-glycoprotein (PGP) was investigated in the disposition of ketobemidone in vitro. Formation of norketobemidone from ketobemidone was studied and compared with the activities of 11 major CYP

The mu1 and mu2 opioid receptor binding of ketobemidone, norketobemidone and 3-dimethylamino-1,1-diphenylbutene.

K Kristensen et al.

Pharmacology & toxicology, 79(2), 103-104 (1996-08-01)

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