产品名称
来氟米特杂质A, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2
SMILES string
Nc1ccc(cc1)C(F)(F)F
InChI key
ODGIMMLDVSWADK-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
leflunomide
manufacturer/tradename
EDQM
refractive index
n20/D 1.483 (lit.)
bp
83 °C/12 mmHg (lit.)
density
1.283 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
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Application
Leflunomide impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
B A Maguire et al.
Molecular microbiology, 23(2), 237-245 (1997-01-01)
Strain BM108 of Escherichia coli has a chromosomal mutation in the rpmB,G operon that prevents synthesis of ribosomal proteins L28 and L33. The mutation was lethal unless synthesis of protein L28 was induced from a plasmid. Without protein L28, RNA
R E Cilley et al.
Journal of pediatric surgery, 35(1), 113-118 (2000-01-26)
The mechanisms by which static airway pressures in the developing lung affect development are unknown. The in vitro murine fetal lung model with airway ligation reproduces the phenomenon of intraluminal airway pressure in developing lungs. We have applied the technique
V Kruft et al.
Biochimie, 73(7-8), 855-860 (1991-07-01)
The complete amino acid sequences of 3 proteins from the 50S subunit of Bacillus stearothermophilus ribosomes were determined by N-terminal sequence analysis and by sequencing of overlapping fragments obtained from enzymatic digestions and chemical cleavages. The proteins BstL28, BstL33 and
B A Maguire et al.
Biochimica et biophysica acta, 1353(2), 137-147 (1997-08-07)
The rpmB,G operon of Escherichia coli codes for proteins L28 and L33 of the larger (50S) ribosomal subunit. Strains with mutations in this operon can help define the roles of these proteins in ribosome synthesis and function. One such strain
B A Maguire et al.
Journal of bacteriology, 179(8), 2486-2493 (1997-04-01)
The rpmBG operon of Escherichia coli codes for ribosomal proteins L28 and L33. Two strains with mutations in the operon are AM81, whose ribosomes lack protein L28, and AM90, whose ribosomes are without protein L33. Neither strain showed major defects
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