InChI
1S/C5H4ClN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)
SMILES string
Nc1nc(Cl)nc2nc[nH]c12
InChI key
HBJGQJWNMZDFKL-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
cladribine
manufacturer/tradename
EDQM
mp
384-389 °C
application(s)
pharmaceutical (small molecule)
format
neat
shipped in
wet ice
storage temp.
−20°C
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Cladribine impurity C EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Peng Li et al.
Biochemical pharmacology, 79(7), 1015-1024 (2009-11-10)
Since the heterologous tolerance that develops after chronic morphine administration has been proposed to be an adaptive process, it follows that the time course of the change in the cellular components should coincide with the time course of the altered
Laura Willems et al.
Journal of molecular and cellular cardiology, 38(2), 245-256 (2005-02-09)
Aging is associated with reduced tolerance to ischemic insult, and genesis of this intolerant phenotype is poorly understood. We characterized effects of aging and gender on cardiovascular function and cell damage during 20 min ischemia and 60 min reperfusion in
Kinga Banach et al.
Nucleosides, nucleotides & nucleic acids, 24(5-7), 465-469 (2005-10-27)
A new kinetic model is presented for analysis of experimental data of oxidation process catalyzed by milk xanthine oxidase. The kinetics for two substrates, xanthine and its analog 2-chloroadenine, in a broad pH range (5.8-9.0) are best described by an
P Hentosh et al.
Nucleic acids research, 19(11), 3143-3148 (1991-06-11)
The purine analog, 2-chloro-2'-deoxyadenosine triphosphate (CldATP), was incorporated enzymatically in place of dATP into the minus strand of M13mp18 duplex DNA. Its effect on protein-DNA interactions was assessed by determining the amount of DNA cleavage by type II restriction endonucleases.
Synnöve Lindemalm et al.
Cancer letters, 210(2), 171-177 (2004-06-09)
The nucleoside analog 2-chlorodeoxyadenosine (Cladribine, CdA) is used in the treatment of patients with several hematological malignancies. After administration of CdA, the major catabolite measured in plasma and urine is 2-chloroadenine (CAde). This study was performed to determine the pharmacokinetics
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