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Y0000616

Tropisetron

Name: Tropisetron
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

ICS-205,930, Navoban, endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-ol Indol-3-yl-carboxylate 单盐酸盐

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关于此项目

经验公式（希尔记法）:

C₁₇H₂₀N₂O₂ · HCl

化学文摘社编号:

105826-92-4

分子量:

320.81

NACRES:

NA.24

PubChem Substance ID:

329831051

UNSPSC Code:

41116107

MDL number:

MFCD00210221

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属性

grade

pharmaceutical primary standard

API family

tropisetron

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34

InChI

1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H

InChI key

XIEGSJAEZIGKSA-UHFFFAOYSA-N

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Tropisetron hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Selective 5-HT₃ serotonin receptor antagonist.

Tropisetron a selective serotonin 5-HT₃ receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Presynaptic inhibitory effects of fluvoxamine, a selective serotonin reuptake inhibitor, on nociceptive excitatory synaptic transmission in spinal superficial dorsal horn neurons of adult mice.

Orie Tomoyose et al.

Journal of pharmacological sciences, 126(2), 136-145 (2014-09-26)

Fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, has been shown to exert analgesic effects in humans and laboratory animals. However, its effects on spinal nociceptive synaptic transmission have not been fully characterized. Here, whole-cell recordings were made from dorsal horn

全球贸易项目编号

货号	GTIN
Y0000616	04061833795903