InChI
1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
SMILES string
OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CCCc1ccccc1)CCCc2ccccc2
InChI key
RYHCACJBKCOBTJ-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
alverine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
human ... HNF4A(3172), HTR1A(3350)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Used for studies of pharmacological activity including:
- Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
- Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
- Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
- Drug effects viewed from a signal transduction network perspective
- Enhanced cytotoxic effect of proteasome inhibitor MG132
- Mechanism of action on phasic smooth muscles
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Alverine citrate plus simethicone reduces cecal intubation time in colonoscopy - a randomized study.
Engin Altintaş et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 19(3), 174-179 (2008-12-31)
Successful colonoscopy depends on the insertion of the instrument to the cecum, a detailed examination, and minimal discomfort to the patient during the procedure. The aim of this study was to determine the effects of alverine citrate plus simethicone on
Chinmoy Ghosh et al.
Drug testing and analysis, 2(6), 284-291 (2010-06-22)
A rapid and highly sensitive method for the determination of alverine (ALV) and its metabolite, para hydroxy alverine (PHA), in human plasma using LC-MS/MS in positive ion electrospray ionization (ESI) in multiple reactions monitoring (MRM) mode was developed and validated.
Samia Ammar et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 16(12), 1156-1161 (2009-05-01)
A sesquiterpenoid Bakkenolide (1), and two steroids, (3beta, 22E)-Stigmasta-5, 22-diène-3-ol (Stigmasterol) (2) and stigmasterol 3beta-glucoside (3), isolated from the Hertia cheirifolia (L.) chloroform extract, were evaluated respectively for their spasmolytic and anti-inflammatory activities. We note that these natural products were
Yavuz Beyazit et al.
Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates, 34(5), 352-355 (2011-10-08)
The quality of colon cleansing and the tolerance of patients to the procedure are two major determinants of the quality of a colonoscopy. Many bowel-cleansing regimens are known, but there is no ideal regimen. Alverine citrate (Relaxyl, Spasmonal) is a
Alverine citrate, simeticone, and Rome III irritable bowel syndrome.
A C Ford
Alimentary pharmacology & therapeutics, 31(7), 767-768 (2010-04-27)
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