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文件

Y0000771

培哚普利

Name: 培哚普利
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

Perindopril erbumine, (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt, S-9490

经验公式（希尔记法）:

C₁₉H₃₂N₂O₅· C₄H₁₁N

CAS号:

107133-36-8

分子量:

441.60

MDL编号:

MFCD02313824

PubChem化学物质编号:

329831141

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

perindopril

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CC(C)(C)N.CCC[C@H](N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(O)=O)C(=O)OCC

InChI

1S/C19H32N2O5.C4H11N/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24;1-4(2,3)5/h12-16,20H,4-11H2,1-3H3,(H,23,24);5H2,1-3H3/t12-,13-,14-,15-,16-;/m0./s1

InChI key

IYNMDWMQHSMDDE-MHXJNQAMSA-N

Gene Information

human ... ACE(1636)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Perindopril for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

Perindopril erbumine is an angiotensin converting enzyme (ACE) inhibitor; antihypertensive; becomes hydrolyzed in vivo to the active diacid metabolite; unlike the other ACE inhibitors, inhibits tumor growth in hepatocellular carcinoma cells due to suppression of VEGF levels; also suppresses angiotensin II production in vitro. Long-term therapy with this agent has a beneficial effect on the cerebral circulation by improving cerebral perfusion reserve in patients with previous minor stroke.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1510903

1510999

1510947

1510925

1510936

1510914

PHR1887

培哚普利叔丁胺盐, Pharmaceutical Secondary Standard; Certified Reference Material

BP1073

Perindopril erbumine, British Pharmacopoeia (BP) Reference Standard

PHR3078

L-八氢吲哚-2-羧酸, pharmaceutical secondary standard, certified reference material

象形图

GHS08

警示用语：

Warning

危险声明

H361d

预防措施声明

P201 - P202 - P280 - P308 + P313 - P405 - P501

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Inhibition of AAA in a rat model by treatment with ACEI perindopril.

Fei Xiong et al.

The Journal of surgical research, 189(1), 166-173 (2014-03-08)

The purpose of the present study was to evaluate the effect of a new angiotensin converting enzyme inhibitor perindopril on the formation of experimental abdominal aortic aneurysms (AAAs) in a rat model induced by intraluminal elastase infusion and extraluminal calcium

Applanation tonometry in mice: a novel noninvasive technique to assess pulse wave velocity and arterial stiffness.

Arthur J A Leloup et al.

Hypertension (Dallas, Tex. : 1979), 64(1), 195-200 (2014-04-23)

Arterial stiffening is the root cause of a range of cardiovascular complications, including myocardial infarction, left ventricular hypertrophy, stroke, renal failure, dementia, and death, and a hallmark of the aging process. The most important in vivo parameter of arterial stiffness

Follow-up of blood-pressure lowering and glucose control in type 2 diabetes.

Sophia Zoungas et al.

The New England journal of medicine, 371(15), 1392-1406 (2014-09-23)

In the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) factorial trial, the combination of perindopril and indapamide reduced mortality among patients with type 2 diabetes, but intensive glucose control, targeting a glycated hemoglobin

Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.

Haruka Nishimuta et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1522-1531 (2014-07-06)

Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydrolyzed by

Predicting the effects of blood pressure-lowering treatment on major cardiovascular events for individual patients with type 2 diabetes mellitus: results from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation.

Joep van der Leeuw et al.

Hypertension (Dallas, Tex. : 1979), 65(1), 115-121 (2014-10-15)

Blood pressure-lowering treatment reduces cardiovascular risk in patients with diabetes mellitus, but the effect varies between individuals. We sought to identify which patients benefit most from such treatment in a large clinical trial in type 2 diabetes mellitus. In Action

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