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文件

Y0000819

麻保沙星

Name: 麻保沙星
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

9-氟代-2,3-二氢-3-甲基-10-(4-甲基-哌嗪)-7-氧代-7H-吡啶并[1,2,3-ij][1,2,4]苯并噁二嗪-6-羧酸, Zeniquin^®

经验公式（希尔记法）:

C₁₇H₁₉FN₄O₄

CAS号:

115550-35-1

分子量:

362.36

MDL编号:

MFCD00864820

PubChem化学物质编号:

329831168

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

marbofloxacin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CN1CCN(CC1)c2c(F)cc3C(=O)C(=CN4N(C)COc2c34)C(O)=O

InChI

1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25)

InChI key

BPFYOAJNDMUVBL-UHFFFAOYSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Marbofloxacin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

法律信息

Zeniquin is a registered trademark of Pfizer, Inc.

危险分类

Aquatic Chronic 3

储存分类代码

11 - Combustible Solids

WGK

WGK 2

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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1000309185

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Pharmacokinetic/pharmacodynamic evaluation of marbofloxacin in the treatment of Haemophilus parasuis and Actinobacillus pleuropneumoniae infections in nursery and fattener pigs using Monte Carlo simulations.

C Vilalta et al.

Journal of veterinary pharmacology and therapeutics, 37(6), 542-549 (2014-06-07)

This study evaluated the theoretical clinical outcome of three marbofloxacin posology regimens in two groups of pigs (weaners and fatteners) for the treatment of Actinobacillus pleuropneumoniae (App) and Haemophilus parasuis (Hp) infection and the appearance of resistant bacteria due to

In vitro selection of resistance to pradofloxacin and ciprofloxacin in canine uropathogenic Escherichia coli isolates.

Xiaoqiang Liu et al.

Veterinary microbiology, 174(3-4), 514-522 (2014-12-04)

This study explored and compared the mechanisms and selective concentration of resistance between a 3rd (pradofloxacin) and 2nd (ciprofloxacin) generation fluoroquinolone. Pradofloxacin- and ciprofloxacin-resistant mutants were selected by stepwise exposure of Escherichia coli (E. coli) to escalating concentrations of pradofloxacin

In vitro selection of RNA aptamers that selectively bind danofloxacin.

Seung Ryul Han et al.

Biochemical and biophysical research communications, 448(4), 397-402 (2014-05-06)

Danofloxacin is a synthetic fluoroquinolone with broad spectrum antibacterial activity that is used for the treatment of respiratory diseases in animal husbandry. However, danofloxacin has many adverse reactions and is toxic to humans. Especially, it detrimentally affects muscle, central nerve

Development of a novel genetically modified bioluminescent-bacteria-based assay for detection of fluoroquinolones in animal-derived foods.

Guyue Cheng et al.

Analytical and bioanalytical chemistry, 406(30), 7899-7910 (2014-10-31)

Fluoroquinolones (FQNs) are broad-spectrum antibacterial agents widely used in animal husbandry and aquaculture. The residues and antimicrobial resistance of such antibiotics are a major public health concern. To realize multianalyte detection of FQN residues, a genetically modified bacterium, Escherichia coli

Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model.

F Yang et al.

Journal of veterinary pharmacology and therapeutics, 37(6), 579-588 (2014-06-07)

Residue depletion of marbofloxacin in broiler chicken after oral administration at 5 mg/kg/day for three consecutive days was studied in this study. The areas under the concentration-time curve from 0 h to ∞ (AUC0-∞ s) of marbofloxacin in tissues and plasma were

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