InChI
1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;
SMILES string
Cl[H].CN(C)CC\C=C1/c2ccccc2COc3ccccc13
InChI key
MHNSPTUQQIYJOT-SJDTYFKWSA-N
grade
pharmaceutical primary standard
API family
doxepin
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Doxepin for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Andrew D Krystal et al.
Sleep, 34(10), 1433-1442 (2011-10-04)
To evaluate the efficacy and safety of doxepin (DXP) 3 mg and 6 mg in adults diagnosed with primary insomnia. The study was a randomized, double-blind, parallel-group, placebo-controlled trial. Patients meeting DSM-IV-TR criteria for primary insomnia were randomized to 35
Anna Maślanka et al.
Journal of AOAC International, 94(6), 1791-1799 (2012-02-11)
Stability of clonazepam, diazepam, haloperidol, and doxepin was determined in acidic solutions. In addition, determination of the kinetic and thermodynamic properties of this stability was carried out. Reaction rate constants (k), half-life times (t(0.1) and t(0.5)), and activation energy (Ea)
Robert S Mansbach et al.
Clinical therapeutics, 33(7), 851-862 (2011-07-05)
Doxepin tablets have recently been approved in the United States in doses of 3 and 6 mg for the treatment of insomnia characterized by difficulty with sleep maintenance. Because no previous thorough QT evaluation of doxepin has been conducted, the
Zhiwei Feng et al.
Journal of molecular graphics & modelling, 39, 1-12 (2012-12-12)
Histamine H4 receptor (H4R), a member of histamine receptor family, which belongs to class A of G-protein coupled receptors (GPCRs), has been reported to play a critical role in histamine-induced chemotaxis in mast cells and eosinophils. Recently, the crystal structure
Donald R Lynch et al.
Cardiology journal, 19(4), 434-438 (2012-07-25)
Vorinostat is a histone deacetylase inhibitor used in the treatment of recurrent or persistent cases of cutaneous T-cell lymphoma (CTCL). A retrospective review of 116 patients from phase I and II clinical trials who had a baseline and at least
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