Merck
CN

Y0000886

1-甲基哌嗪

European Pharmacopoeia (EP) Reference Standard

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别名:
1-Methylpiperazine
经验公式(希尔记法):
C5H12N2
CAS号:
分子量:
100.16
Beilstein:
102724
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

pharmaceutical primary standard

蒸汽密度

3.5 (vs air)

API family

cyclizine

manufacturer/tradename

EDQM

折射率

n20/D 1.466 (lit.)

bp

138 °C (lit.)

密度

0.903 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CN1CCNCC1

InChI

1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3

InChI key

PVOAHINGSUIXLS-UHFFFAOYSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Cyclizine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

警示用语:

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Flam. Liq. 3 - Skin Corr. 1B

储存分类代码

3 - Flammable liquids

WGK

WGK 1

闪点(°F)

102.2 °F - closed cup

闪点(°C)

39 °C - closed cup

法规信息

危险化学品

分析证书(COA)

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Almeqdad Y Habashneh et al.
Archiv der Pharmazie, 347(6), 415-422 (2014-03-13)
A new series of N1-(flavon-6-yl)amidrazones were synthesized by reacting the hydrazonoyl chloride derived from 6-aminoflavone with the appropriate sec-cyclic amines. The antitumor activities of these compounds were evaluated on breast cancer (MCF-7) and leukemic (K562) cell lines. Among the compounds
Jin-Ping Li et al.
Drug design, development and therapy, 9, 1027-1062 (2015-03-04)
Danusertib (Danu) is a pan-inhibitor of Aurora kinases and a third-generation breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (Bcr-Abl) tyrosine kinase inhibitor, but its antitumor effect and underlying mechanisms in the treatment of human breast cancer remain elusive.
Son T Nguyen et al.
Bioorganic & medicinal chemistry, 23(9), 2024-2034 (2015-03-31)
Recently we described a novel pyranopyridine inhibitor (MBX2319) of RND-type efflux pumps of the Enterobacteriaceae. MBX2319 (3,3-dimethyl-5-cyano-8-morpholino-6-(phenethylthio)-3,4-dihydro-1H-pyrano[3,4-c]pyridine) is structurally distinct from other known Gram-negative efflux pump inhibitors (EPIs), such as 1-(1-naphthylmethyl)-piperazine (NMP), phenylalanylarginine-β-naphthylamide (PAβN), D13-9001, and the pyridopyrimidine derivatives. Here

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