产品名称
厚朴酚, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
SMILES string
Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O
InChI key
VVOAZFWZEDHOOU-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
magnolol, magnolia officialis
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
−20°C
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Biochem/physiol Actions
厚朴酚是从木兰科植物 厚朴的根和茎皮中分离得到的一种具有生物活性的植物成分 ，具有抗真菌、 抗菌 和抗氧化作用。厚朴酚还通过干扰 NF-κ 而显示抗炎活性 B 信号传导。由于其能够抑制 IL-6 诱导的 STAT3 活化，因此其似乎也具有与血管疾病（如动脉粥样硬化）相关的抗炎属性。
Application
Magnolol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yong Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(23), 3526-3530 (2013-03-13)
Magnolol is one of main active constituents from Magnolia officinalis, a widely used traditional Chinese medicine. Previous studies have proved its multiple pharmacological effects, such as anti-oxidation, anti-microbial and anti-tumor. In recent years, more and more studies have focused on
A-Rang Im et al.
Environmental toxicology and pharmacology, 39(1), 417-423 (2015-01-07)
In this study, we evaluated the anti-photoaging activity of magnolol in UV-irradiated hairless mice, and hypothesized that magnolol would prevent photoaging in these animals. The inhibitory effect of magnolol on wrinkle formation was determined by analyzing the skin replica, histologically
Chanju Lee et al.
Frontiers in immunology, 11, 77-77 (2020-03-03)
Cancer chemotherapy induces sarcopenia, which is a rapid loss of muscle mass that directly restricts daily activities and leads to poor quality of life and increased mortality. Although hormone-related therapies have been used to improve appetite and nutritional status, current
Jui-Lung Shen et al.
Molecules (Basel, Switzerland), 15(9), 6452-6465 (2010-09-30)
Chinese herbs have been and still are widely used as important remedies in Oriental medicine. Over the recent years, a variety of biologically active constituents have been isolated from these sources and confirmed to have multifunctional activity in experimental studies.
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