Merck
CN
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文件

Y0001422

2-丙基戊酸

European Pharmacopoeia (EP) Reference Standard

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别名:
丙戊酸
线性分子式:
(CH3CH2CH2)2CHCO2H
CAS号:
99-66-1
分子量:
144.21
MDL编号:
MFCD00002672
PubChem化学物质编号:
329831418
NACRES:
NA.24

等级

pharmaceutical primary standard

API family

valproic acid

manufacturer/tradename

EDQM

折射率

n20/D 1.425 (lit.)

bp

220 °C (lit.)

密度

0.9 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CCCC(C(O)=O)CCC

InChI

1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

InChI key

NIJJYAXOARWZEE-UHFFFAOYSA-N

Gene Information

human ... ALDH5A1(7915)

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Valproic acid for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

抗惊厥药，同时还具有双相障碍症情绪稳定剂的功效

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

231.8 °F - closed cup

闪点(°C)

111 °C - closed cup

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Anton Pohanka et al.
Scandinavian journal of clinical and laboratory investigation, 74(7), 648-652 (2014-07-26)
Therapeutic drug monitoring (TDM) of the antiepileptic drug valproic acid (VPA) is recommended in patients with multiple drug therapy or with concomitant disabilities to ensure treatment efficacy and avoid adverse reactions in both adults and children. The use of sampling
Hubert Arokium et al.
PloS one, 9(10), e108682-e108682 (2014-10-08)
Long interspersed element-1 (LINE-1 or L1) retrotransposition induces insertional mutations that can result in diseases. It was recently shown that the copy number of L1 and other retroelements is stable in induced pluripotent stem cells (iPSCs). However, by using an
Alexa P Vitins et al.
Archives of toxicology, 88(8), 1573-1588 (2014-02-19)
Liver injury is the leading cause of drug-induced toxicity. For the evaluation of a chemical compound to induce toxicity, in this case steatosis or fatty liver, it is imperative to identify markers reflective of mechanisms and processes induced upon exposure
Zhida Liu et al.
Scientific reports, 4, 7266-7266 (2014-12-02)
In the history of vaccine development, the synthetic vaccine is a milestone that is in stark contrast with traditional vaccines based on live-attenuated or inactivated microorganisms. Synthetic vaccines not only are safer than attenuated or inactivated microorganisms but also provide
Jennifer A Corcoran et al.
PLoS pathogens, 11(1), e1004597-e1004597 (2015-01-09)
Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious cause of several AIDS-related cancers, including the endothelial cell (EC) neoplasm Kaposi's sarcoma (KS). KSHV-infected ECs secrete abundant host-derived pro-inflammatory molecules and angiogenic factors that contribute to tumorigenesis. The precise contributions of viral
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