Y0001637
左卡巴斯汀
European Pharmacopoeia (EP) Reference Standard
别名:
左卡巴斯汀 盐酸盐, R50547, [3S-[1（顺式），3α，4β]]-1-[4-氰基-4-（4-氟苯基）环己基]-3-甲基-4-苯基-4-哌啶羧酸, 左旋多巴, 立复汀
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关于此项目
经验公式（希尔记法）:
C26H29N2O2F·HCl
CAS Number:
分子量:
456.98
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
pharmaceutical primary standard
API类
levocabastine
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
Cl[H].C[C@@H]1CN(CC[C@]1(C(O)=O)c2ccccc2)[C@@H]3CC[C@@](CC3)(C#N)c4ccc(F)cc4
InChI
1S/C26H29FN2O2.ClH/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20;/h2-10,19,23H,11-17H2,1H3,(H,30,31);1H/t19-,23-,25-,26-;/m1./s1
InChI key
OICFWWJHIMKBCD-VALQNVSPSA-N
基因信息
human ... HRH1(3269)
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Levocabastine for system suitability 2 EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
生化/生理作用
非肽类组胺H1 受体拮抗剂；神经降压素NTS2受体配体。
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Megumi Akiyoshi et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 119(3), 175-184 (2002-03-28)
Levocabastine is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils. Both histamine and antigens induced conjunctivitis was inhibited by levocabastine in several
Jian Jiao et al.
ORL; journal for oto-rhino-laryngology and its related specialties, 76(3), 127-136 (2014-06-28)
The aim of this study was to investigate the effect of the corticosteroids, the antihistamines, and the preservatives benzalkonium chloride (BKC) and potassium sorbate (PS) in intranasal medications on human nasal epithelial ciliary beat frequency (CBF). Primary ciliated epithelial cell
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