Merck
CN

Y0001692

伊马替尼 甲磺酸酯

European Pharmacopoeia (EP) Reference Standard

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别名:
4-[(4-甲基-1-哌嗪基)甲基]-N-[4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯基]苯甲酰胺 甲磺酸酯, 4-[(4-甲基哌嗪-1-基)甲基]-N-(4-甲基-3-{[4-(吡啶-3-基)嘧啶-2-基]氨基}苯基)苯甲酰胺 甲磺酸酯, CGP 57148, STI-571, 伊马替尼 甲磺酸酯, 格列卫, 甲磺酸伊马替尼
Empirical Formula (Hill Notation):
C29H31N7O · CH4O3S
分子量:
589.71
NACRES:
NA.24

等级

pharmaceutical primary standard

API family

imatinib

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

InChI

1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)

InChI key

YLMAHDNUQAMNNX-UHFFFAOYSA-N

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此商品
Y0001691SML1027Y0001693
vibrant-m

Y0001692

伊马替尼 甲磺酸酯

vibrant-m

Y0001691

伊马替尼 甲磺酸酯

Sigma-Aldrich

Sigma-Aldrich

SML1027

伊马替尼 甲磺酸酯

vibrant-m

Y0001693

Imatinib impurity F

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

-

format

neat

API family

imatinib

API family

imatinib

API family

-

API family

imatinib

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Imatinib for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

甲磺酸伊马替尼是一种具有抗肿瘤活性的酪氨酸激酶抑制剂。伊马替尼能够抑制由bcr-abl致癌基因编码的Bcr-Abl激酶以及由c-kit和血小板源性生长因子受体(PDGFR)致癌基因编码的受体酪氨酸激酶。甲磺酸伊马替尼通过抑制由CML中费城染色体异常产生的Bcr-Abl酪氨酸激酶,降低了白血病CML和ALL的增殖并诱导其凋亡。 在过度表达c-kit的疾病中,如胃肠道间质瘤(GIST),通过抑制c-kit酪氨酸活性,可抑制肥大细胞和细胞增殖。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

象形图

Health hazard

警示用语:

Warning

危险声明

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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