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Merck
CN

Y0001933

系统适用性试验用他克莫司

European Pharmacopoeia (EP) Reference Standard

别名:

FK-506 一水合物, 他克莫司

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关于此项目

经验公式(希尔记法):
C44H69NO12 · H2O
化学文摘社编号:
分子量:
822.03
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
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InChI

1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1

SMILES string

O.CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]2OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@]4(O)O[C@H]([C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)OC)[C@H](C[C@H]4C)OC

InChI key

NWJQLQGQZSIBAF-MLAUYUEBSA-N

grade

pharmaceutical primary standard

API family

tacrolimus

manufacturer/tradename

EDQM

format

neat

storage temp.

2-8°C

Gene Information

human ... FKBP1A(2280)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Tacrolimus for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

FK-506是一种有效的免疫抑制剂,神经保护和神经再生剂,以及 体外 T细胞增殖阻滞剂。FK-506可破坏T淋巴细胞中钙调神经磷酸酶介导的信号转导,并与FK-506结合蛋白-12(FKBP12)相互作用。
FK-506是一种有效的免疫抑制剂;神经保护和神经再生; 体外 T细胞增殖阻滞剂。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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