D0754
3,5-二碘- L -酪氨酸 二水合物
≥98.0% (HPLC), suitable for ligand binding assays
别名:
3,5-diiodo-L-tyrosine hydrate (1:2)
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关于此项目
经验公式（希尔记法）:
C9H9I2NO3 · 2H2O
化学文摘社编号:
分子量:
469.01
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
206-092-0
MDL number:
Beilstein/REAXYS Number:
2218691
产品名称
3,5-二碘- L -酪氨酸 二水合物, crystalline
InChI key
NYPYHUZRZVSYKL-ZETCQYMHSA-N
InChI
1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1
SMILES string
N[C@@H](Cc1cc(I)c(O)c(I)c1)C(O)=O
assay
≥98.0% (HPLC)
form
crystalline
technique(s)
ligand binding assay: suitable
color
white
mp
200 °C (dec.) (lit.)
solubility
4 M NH4OH in methanol: 50 mg/mL, clear, yellow-green
storage temp.
−20°C
Quality Level
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Application
用于测定卤化酪氨酸和甲状腺激素转氨酶的底物。 甲状腺激素生物合成和替代代谢途径中的中间体。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Sangeeta Kumari et al.
Journal of the American Society for Mass Spectrometry, 18(8), 1516-1524 (2007-06-26)
L-Tyrosine and iodinated L-tyrosines, i.e., 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine, are successfully used as chiral references for the chiral discrimination of aliphatic, acidic, and aromatic amino acids. Chiral discrimination is achieved by investigating the collision-induced dissociation spectra of the trimeric complex [Cu(II)(ref)(2)(A)
Jana Frýdlová et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 863(1), 135-140 (2008-02-08)
The interaction of porcine pepsin A with immobilized derivatives of aromatic amino acids was investigated. Divinyl sulfone-activated Sepharose was used to immobilize N-acetyl-l-phenylalanine and 3,5-diiodo-l-tyrosine via their free carboxyl groups and l-tyrosine via its amino group. Immobilized l-tyrosine was iodinated
Yining Zheng et al.
Talanta, 69(1), 107-112 (2008-10-31)
In this paper, a new method for separation, identification and quantitation of iodotyrosines and iodothyronines [3-monoiodo-L-tyrosine (MIT), 3,5-diiodo-L-tyrosine (DIT), L-thyronine (T(0)), 3,5-diiodo-L-thyronine (T(2)), 3,5,3'-triiodo-L-thyronine (T(3)) and 3,3',5,5'-tetraiodo-L-thyronine (T(4))] was described by using capillary electrophoresis with photodiode-array ultraviolet-visible detection (CE-UV). The
A Balsam et al.
The Journal of clinical investigation, 72(4), 1234-1245 (1983-10-01)
Studies were performed to elucidate the nature of the pathway of hepatic thyroxine (T4) metabolism that is activated by inhibitors of liver catalase. For this purpose, the metabolism of T4 in homogenates of rat liver was monitored with T4 labeled
M. Nakano
Methods in Enzymology, 17A, 660-660 (1970)
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