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D9766

双嘧达莫

Name: 双嘧达莫
Brand: SIGMA

≥98% (HPLC), powder, phosphodiesterase V inhibitor

别名:

NSC 515776, NSC 619103

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关于此项目

经验公式（希尔记法）:

C₂₄H₄₀N₈O₄

化学文摘社编号:

58-32-2

分子量:

504.63

NACRES:

NA.77

PubChem Substance ID:

24277705

UNSPSC Code:

41106305

EC Number:

200-374-7

MDL number:

MFCD00010555

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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产品名称

双嘧达莫, ≥98% (HPLC)

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

yellow

mp

165-166 °C (lit.)

solubility

DMSO: soluble, ethanol: soluble

originator

Boehringer Ingelheim

storage temp.

room temp

SMILES string

OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO

InChI

1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2

InChI key

IZEKFCXSFNUWAM-UHFFFAOYSA-N

Gene Information

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General description

双嘧达莫阻止细胞摄取腺苷。作为一种平衡核苷转运蛋白 1 (ENT1) 抑制剂发挥作用。

Application

双嘧达莫已用于：

进行体外生长抑制试验 (40)
测定其预防子宫肌层收缩的能力 (41)
确定其对烟酰胺腺嘌呤二核苷酸 (NAD +) 诱导的细胞内三磷酸腺苷 (ATP) 水平增加的作用 (42)
，防止烟酰胺核苷 (NR) 诱导的轴突保护作用 (43)

Biochem/physiol Actions

磷酸二酯酶 V 选择性抑制剂 (PDE 5)；强效冠脉扩张药物；腺苷转运抑制剂；血小板聚集抑制剂。

Features and Benefits

该化合物是受体分类及信号转导手册上磷酸二酯酶页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

该化合物由 Boehringer Ingelheim 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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全球贸易项目编号

货号	GTIN
D9766-10G	04061832897882
D9766-25G	04061832897899
D9766-5G	04061833591109
D9766-1G	04061826682494

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