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Merck
CN

R1908

Sigma-Aldrich

Remifentanil hydrochloride

≥97% (HPLC), Mu opioid receptor agonist, powder

别名:

3-[methoxycarbonyl-4-[(1-oxopropyl)phenylamino]1-piperidine]propanoic acid methyl ester hydrochloride, GI-87084B, Remifentanyl, Ultiva

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关于此项目

经验公式（希尔记法）:
C20H28N2O5·HCl
化学文摘社编号:
132539-07-2
分子量:
412.91
MDL编号:
MFCD00910882
UNSPSC代码:
12352200
PubChem化学物质编号:
329824010

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产品名称

Remifentanil hydrochloride, ≥97% (HPLC), powder

质量水平

100

方案

≥97% (HPLC)

表单

powder

药品控制

USDEA Schedule II; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

储存条件

desiccated

颜色

white to off-white

溶解性

H2O: ≥20 mg/mL

储存温度

2-8°C

SMILES字符串

O=C(CC)N(C1(CCN(CCC(OC)=O)CC1)C(OC)=O)C2=CC=CC=C2.[H]Cl

InChI

1S/C20H28N2O5.ClH/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2;/h5-9H,4,10-15H2,1-3H3;1H

InChI key

WFBMIPUMYUHANP-UHFFFAOYSA-N

基因信息

human ... OPRM1(4988)

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相关类别

生化/生理作用

Remifentanil hydrochloride is a mu opioid receptor agonist, anesthetic, and analgesic compound.
Remifentanil hydrochloride is a mu opioid receptor agonist, anesthetic, and analgesic compound. Remifentanil was developed as an ultra-short-acting mu opioid receptor agonist with improved pharmacodynamic properties.

特点和优势

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H371

危险分类

STOT SE 2

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000209575
0000209575
0000143588
0000121600
0000120137

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Anthony G Doufas et al.
PloS one, 8(1), e54807-e54807 (2013-02-06)
Obstructive sleep apnea (OSA) is characterized by recurrent nocturnal hypoxia and sleep disruption. Sleep fragmentation caused hyperalgesia in volunteers, while nocturnal hypoxemia enhanced morphine analgesic potency in children with OSA. This evidence directly relates to surgical OSA patients who are
N A Pedersen et al.
Acta anaesthesiologica Scandinavica, 57(8), 988-995 (2013-07-10)
Magnetic resonance imaging (MRI) of children is generally performed under sedation or with general anaesthesia (GA), but the ideal regimen has not been found. The aim of this study was to see if propofol-remifentanil would be a suitable alternative for
Arne Kristian Skulberg et al.
European journal of clinical pharmacology, 74(7), 873-883 (2018-03-24)
This study aimed to develop a model for pharmacodynamic and pharmacokinetic studies of naloxone antagonism under steady-state opioid agonism and to compare a high-concentration/low-volume intranasal naloxone formulation 8 mg/ml to intramuscular 0.8 mg. Two-way crossover in 12 healthy volunteers receiving naloxone while
A Harsten et al.
British journal of anaesthesia, 111(3), 391-399 (2013-04-13)
This study was undertaken to compare the effects of general anaesthesia (GA) and spinal anaesthesia (SA) on the need for postoperative hospitalization and early postoperative comfort in patients undergoing fast-track total knee arthroplasty (TKA). One hundred and twenty subjects were
Tor D Wager et al.
The New England journal of medicine, 368(15), 1388-1397 (2013-04-12)
Persistent pain is measured by means of self-report, the sole reliance on which hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds promise for identifying objective measures of pain, but brain measures that are sensitive and specific to physical
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