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Merck
CN

R1908

Remifentanil hydrochloride

≥97% (HPLC), Mu opioid receptor agonist, powder

别名:

3-[methoxycarbonyl-4-[(1-oxopropyl)phenylamino]1-piperidine]propanoic acid methyl ester hydrochloride, GI-87084B, Remifentanyl, Ultiva

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关于此项目

经验公式（希尔记法）:
C20H28N2O5·HCl
化学文摘社编号:
132539-07-2
分子量:
412.91
PubChem Substance ID:
329824010
UNSPSC Code:
12352200
MDL number:
MFCD00910882

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产品名称

Remifentanil hydrochloride, ≥97% (HPLC), powder

InChI key

WFBMIPUMYUHANP-UHFFFAOYSA-N

SMILES string

O=C(CC)N(C1(CCN(CCC(OC)=O)CC1)C(OC)=O)C2=CC=CC=C2.[H]Cl

InChI

1S/C20H28N2O5.ClH/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2;/h5-9H,4,10-15H2,1-3H3;1H

assay

≥97% (HPLC)

form

powder

drug control

USDEA Schedule II; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
kontrollierte Droge in Deutschland

Quality Level

100

Gene Information

human ... OPRM1(4988)

storage condition

desiccated

color

white to off-white

solubility

H2O: ≥20 mg/mL

storage temp.

2-8°C

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相关类别

Biochem/physiol Actions

Remifentanil hydrochloride is a mu opioid receptor agonist, anesthetic, and analgesic compound.
Remifentanil hydrochloride is a mu opioid receptor agonist, anesthetic, and analgesic compound. Remifentanil was developed as an ultra-short-acting mu opioid receptor agonist with improved pharmacodynamic properties.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H371

Hazard Classifications

STOT SE 2

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000209575
0000209575
0000143588
0000121600
0000120137

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M Gruenewald et al.
British journal of anaesthesia, 110(6), 1024-1030 (2013-03-09)
Measurement of the balance between nociception and anti-nociception during anaesthesia is challenging and not yet clinically established. The Surgical pleth index (SPI), derived from photoplethysmography, was proposed as a surrogate measure of nociception. Recently, the analgesia nociception index (ANI) derived
Tor D Wager et al.
The New England journal of medicine, 368(15), 1388-1397 (2013-04-12)
Persistent pain is measured by means of self-report, the sole reliance on which hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds promise for identifying objective measures of pain, but brain measures that are sensitive and specific to physical
Arne Kristian Skulberg et al.
European journal of clinical pharmacology, 74(7), 873-883 (2018-03-24)
This study aimed to develop a model for pharmacodynamic and pharmacokinetic studies of naloxone antagonism under steady-state opioid agonism and to compare a high-concentration/low-volume intranasal naloxone formulation 8 mg/ml to intramuscular 0.8 mg. Two-way crossover in 12 healthy volunteers receiving naloxone while
A Harsten et al.
British journal of anaesthesia, 111(3), 391-399 (2013-04-13)
This study was undertaken to compare the effects of general anaesthesia (GA) and spinal anaesthesia (SA) on the need for postoperative hospitalization and early postoperative comfort in patients undergoing fast-track total knee arthroplasty (TKA). One hundred and twenty subjects were
N A Pedersen et al.
Acta anaesthesiologica Scandinavica, 57(8), 988-995 (2013-07-10)
Magnetic resonance imaging (MRI) of children is generally performed under sedation or with general anaesthesia (GA), but the ideal regimen has not been found. The aim of this study was to see if propofol-remifentanil would be a suitable alternative for
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