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Merck
CN

68088

N-Nitrosomethylethylamine

analytical standard

别名:

N-Nitroso-N-methylethylamine, NMEA

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关于此项目

经验公式(希尔记法):
C3H8N2O
化学文摘社编号:
分子量:
88.11
UNSPSC Code:
12352116
NACRES:
NA.24
MDL number:
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grade

analytical standard

Quality Level

assay

≥95%

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

SMILES string

N(N=O)(CC)C

InChI key

RTDCJKARQCRONF-UHFFFAOYSA-N

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitrosomethylethylamine is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.

Application

N-Nitrosomethylethylamine may be used as an analytical reference standard for the quantification of nitrosamine impurities in metformin drug products using liquid chromatography-high resolution mass spectrometry (LC-HRMS).

Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.


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Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

170.1 °F - closed cup

flash_point_c

76.7 °C - closed cup

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Lot/Batch Number

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A comprehensive approach for N-nitrosamine determination in pharmaceuticals using a novel HILIC-based solid phase extraction and LC-HRMS
Parfant, et al.
Talanta, 282, 126752-126752 (2025)