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Merck
CN

BP1100

硫酸羟氯喹

British Pharmacopoeia (BP) Reference Standard

别名:

7-氯-4-[4-（N-乙基-N-b-羟乙基氨基）-1-甲基丁氨基] 喹啉硫酸盐

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关于此项目

经验公式（希尔记法）:
C18H26ClN3O · H2SO4
化学文摘社编号:
747-36-4
分子量:
433.95
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00078203

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InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

SMILES string

OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI key

JCBIVZZPXRZKTI-UHFFFAOYSA-N

grade

pharmaceutical primary standard

agency

BP

API family

hydroxychloroquine

form

solid

shelf life

limited shelf life, expiry date on the label

packaging

pkg of 100 mg

manufacturer/tradename

BP

color

off-white

mp

238-241 °C

solubility

water: soluble

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

shipped in

ambient

storage temp.

2-8°C

Gene Information

human ... TLR7(51284), TLR9(54106)

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General description

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydroxychloroquine sulfate BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Hydroxychloroquine Tablets

    • Biochem/physiol Actions

    硫酸羟氯喹是一种抗炎（通过肿瘤坏死因子）、疾病调节抗风湿药物（DMARD）和血红素聚合酶抑制剂。
    硫酸羟氯喹是一种抗炎（通过肿瘤坏死因子）、疾病调节抗风湿药物（DMARD）和血红素聚合酶抑制剂。 它可用于治疗疟疾。

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

    pictograms

    Exclamation mark
    GHS07

    signalword

    Warning

    Hazard Classifications

    Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

    存储类别

    11 - Combustible Solids

    wgk

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

    历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    Famotidine
    British Pharmacopeia
    British Pharmacopoeia, 44(12), 1000-1004 (2020)
    Seminars in Arthritis and Rheumatism, 43(2), 264-272 (2013)
    Compatibility study of hydroxychloroquine sulfate with pharmaceutical excipients using thermal and nonthermal techniques for the development of hard capsules
    Moraes ANF, et al.
    Journal of Thermal Analysis and Calorimetry, 421 (2019)
    Pharmacokinetics and bioequivalence study of hydroxychloroquine sulfate tablets in Chinese healthy volunteers by LC--MS/MS
    Fan HW, et al.
    Rheumatology and therapy, 2(2) (2015)
    A rapid and reliable method for the quantitation of hydroxychloroquine in serum using turbulent flow liquid chromatography-tandem mass spectrometry
    Fuzery AK, et al.
    Clinica Chimica Acta; International Journal of Clinical Chemistry, 421 (2013)
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