InChI
1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
SMILES string
OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI key
JCBIVZZPXRZKTI-UHFFFAOYSA-N
grade
pharmaceutical primary standard
agency
BP
API family
hydroxychloroquine
form
solid
shelf life
limited shelf life, expiry date on the label
packaging
pkg of 25 mg
manufacturer/tradename
BP
storage condition
OK to freeze
color
off-white
mp
238-241 °C
solubility
water: soluble
application(s)
pharmaceutical
pharmaceutical small molecule
format
neat
shipped in
ambient
storage temp.
2-8°C
Gene Information
human ... TLR7(51284), TLR9(54106)
General description
2-[4-[(7-Chloro-4-quinolinyl)amino]pentyl] amino ethanol (Hydroxychloroquine Sulfate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
2-[4-[(7-Chloro-4-quinolinyl)amino]pentyl] amino ethanol BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.
Biochem/physiol Actions
硫酸羟氯喹是一种抗炎（通过肿瘤坏死因子）、疾病调节抗风湿药物（DMARD）和血红素聚合酶抑制剂。
硫酸羟氯喹是一种抗炎（通过肿瘤坏死因子）、疾病调节抗风湿药物（DMARD）和血红素聚合酶抑制剂。 它可用于治疗疟疾。
Packaging
Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hydroxychloroquine Sulfate
British Pharmacopeia, 2021
British Pharmacopoeia, 44(12), 1000-1004 (2021)
Seminars in Arthritis and Rheumatism, 43(2), 264-272 (2013)
Pharmacokinetics and bioequivalence study of hydroxychloroquine sulfate tablets in Chinese healthy volunteers by LC--MS/MS
Fan HW, et al.
Rheumatology and therapy, 2(2) (2015)
Compatibility study of hydroxychloroquine sulfate with pharmaceutical excipients using thermal and nonthermal techniques for the development of hard capsules
Moraes ANF, et al.
Journal of Thermal Analysis and Calorimetry, 421 (2019)
A rapid and reliable method for the quantitation of hydroxychloroquine in serum using turbulent flow liquid chromatography-tandem mass spectrometry
Fuzery AK, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 421 (2013)
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