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线性分子式:
(CH3)2CHCH=CH(CH2)4CONHCH2C6H3-4-(OH)-3-(OCH3)
化学文摘社编号:
分子量:
305.41
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2816484
InChI key
YKPUWZUDDOIDPM-SOFGYWHQSA-N
SMILES string
COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O
InChI
1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
grade
pharmaceutical primary standard
API family
capsaicin
manufacturer/tradename
USP
mp
62-65 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
human ... TRPV1(7442)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Capsaicin USP reference standard for use in specified quality tests and assays.
Also used to prepare standard solutions for the assay, identification, composition and strength analysis according to the given below monographs of United States Pharmacopeia (USP):
Also used to prepare standard solutions for the assay, identification, composition and strength analysis according to the given below monographs of United States Pharmacopeia (USP):
- Capsaicin
- Capsicum Oleoresin
- Capsicum
- Ginger Tincture
Biochem/physiol Actions
原型香草受体激动剂。 神经毒素；激活产生无髓C纤维的感觉神经元，其中许多含有P物质。 局部使用可使感觉神经末梢脱敏，从而产生反常的抗伤害感受作用；全身给药可对辣椒素敏感的细胞产生神经毒性，尤其是在新生动物中。辣椒的活性成分。
原型香草受体激动剂；神经毒素。辣椒的活性成分。
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
signalword
Danger
Hazard Classifications
Acute Tox. 2 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
法规信息
涉药品监管产品
此项目有
Capsaicin
United States Pharmacopeia, 727-727 (2013)
Capsicum Oleoresin
United States Pharmacopeia, 38(4), 730-730 (2019)
Ginger Tincture
United States Pharmacopeia, 40(6), 5030-5030 (2020)
Capsicum
United States Pharmacopeia, 38(4), 728-728 (2019)
Sheena Derry et al.
The Cochrane database of systematic reviews, 2(2), CD007393-CD007393 (2013-03-02)
Topical creams with capsaicin are used to treat peripheral neuropathic pain. Following application to the skin capsaicin causes enhanced sensitivity, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitisation. High-concentration (8%) capsaicin patches were developed to
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