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Merck
CN

1118000

USP

磷酸氯喹

United States Pharmacopeia (USP) Reference Standard

别名:

氯喹 二磷酸盐, N4-(7-氯-4-喹啉基)-N1,N1-二甲基-1,4-戊二胺 二磷酸盐

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关于此项目

经验公式（希尔记法）:
C18H26ClN3 · 2H3PO4
化学文摘社编号:
50-63-5
分子量:
515.86
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749320
MDL number:
MFCD00069852
Beilstein/REAXYS Number:
4223142

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产品名称

磷酸氯喹, United States Pharmacopeia (USP) Reference Standard

InChI key

QKICWELGRMTQCR-UHFFFAOYSA-N

SMILES string

OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

chloroquine

form

powder

packaging

pkg of 500 mg

manufacturer/tradename

USP

storage condition

protect from light

color

yellow

pH

3.5-4.5 (10% in aqueous solution, pH <6.0)

mp

200 °C (dec.) (lit.)

solubility

water: 50 g/L
benzene: practically insoluble
chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Analysis Note

这些产品仅供测试和分析使用。它们不适用于人类或动物的给药，不可用于诊断、治疗或治愈任何疾病。

Application

磷酸氯喹USP参考标准品，预期用途是USP规定的指定质量测试和检测。也用于USP各论，例如：
  • 盐酸阿莫地喹
  • 盐酸阿莫地喹片
  • 氯喹
  • 磷酸氯喹
  • 磷酸氯喹复方口服混悬液
  • 磷酸氯喹片

General description

磷酸氯喹是氯喹的一种盐，是一种能有效抑制人类病毒感染的9-氨基喹啉类药物。

Other Notes

可能适用相应的销售限制。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Determination of chloroquine and its decomposition products in various brands of different dosage forms by liquid chromatography
Abdelrahman AN, et al.
Journal of Pharmaceutical and Biomedical Analysis, 12(2), 205-208 (1994)
Cecilia Pessoa Rodrigues et al.
Nature communications, 12(1), 6212-6212 (2021-10-29)
Noncommunicable diseases (NCDs) account for over 70% of deaths world-wide. Previous work has linked NCDs such as type 2 diabetes (T2D) to disruption of chromatin regulators. However, the exact molecular origins of these chronic conditions remain elusive. Here, we identify
Zilong Wang et al.
Brain : a journal of neurology, 144(2), 665-681 (2020-12-29)
Opioids such as morphine are mainstay treatments for clinical pain conditions. Itch is a common side effect of opioids, particularly as a result of epidural or intrathecal administration. Recent progress has advanced our understanding of itch circuits in the spinal
Chloroquine Phosphate USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 959-959 (2020)
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Vincent MJ, et al.
Virology Journal, 2(1), 1-10 (2005)
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实验方案

Chloroquine Phosphate HPLC Assay & Impurity Profiling

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

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