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Merck
CN

1118350

USP

Chloroquine Related Compound D

United States Pharmacopeia (USP) Reference Standard

别名:

7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline, Monodesethylchloroqu​ine

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关于此项目

经验公式（希尔记法）:
C16H22ClN3
化学文摘社编号:
1476-52-4
分子量:
291.82
MDL编号:
MFCD00871808
UNSPSC代码:
41116107
NACRES:
NA.24

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生物来源

synthetic

等级

pharmaceutical primary standard

Agency

USP

API类

chloroquine

表单

powder

包装

pkg of 15 mg

制造商/商品名称

USP

储存条件

protect from light

颜色

tan

沸点

343.4-347 °F (173—175°C; 845.06°F )

mp

176-215.6 °F (80—102°C)

溶解性

chloroform: soluble
dichloromethane: soluble

密度

1.14 g/cm3

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2

InChI

1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)

InChI key

MCYUUUTUAAGOOT-UHFFFAOYSA-N

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相关类别

一般描述

Chloroquine Related Compound D is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans.

应用

Chloroquine Related Compound D USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as Chloroquine Phosphate

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

预防措施声明

P301 + P312 + P330

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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An HPLC method with diode array detector for the simultaneous quantification of chloroquine and desethylchloroquine in plasma and whole blood samples from Plasmodium vivax patients in Vietnam, using quinine as an internal standard
Van Pham T, et al.
Biomedical Chromatography, 30(7), 1104-1111 (2016)
HPLC with ultraviolet detection for the determination of chloroquine and desethylchloroquine in whole blood and finger-prick capillary blood dried on filter paper
Cheomung A and Na-Bangchang K
Journal of Pharmaceutical and Biomedical Analysis, 55(5), 1031-1040 (2011)
Chloroquine Phosphate USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 959-959 (2020)
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Vincent MJ, et al.
Virology Journal, 2(1), 1-10 (2005)

实验方案

Chloroquine Phosphate HPLC Assay & Impurity Profiling

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

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