所有图片(1)

文件

1134233

USP

氢溴酸西酞普兰氢溴酸盐

Name: 氢溴酸西酞普兰 氢溴酸盐
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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所有图片(1)

别名:

1-[3-（二甲氨基）丙基]-1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃甲腈氢溴酸盐

经验公式（希尔记法）:

C₂₀H₂₁FN₂O · HBr

CAS号:

59729-32-7

分子量:

405.30

MDL编号:

MFCD02101306

PubChem化学物质编号:

329749406

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

citalopram

制造商/商品名称

USP

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

InChI

1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H

InChI key

WIHMBLDNRMIGDW-UHFFFAOYSA-N

基因信息

human ... SLC6A4(6532)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Citalopram hydrobromide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

生化/生理作用

有效的选择性 5-羟色胺摄取抑制剂 (K_i = 5.4 nM)；抗抑郁药

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

1134244

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1134255

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1134299

PHR1906

PHR1863

PHR1902

PHR1904

PHR1903

BP1153

氢溴酸西酞普兰氢溴酸盐, British Pharmacopoeia (BP) Reference Standard

PHR1905

PHR1901

BP1154

西酞普兰杂质标准品, British Pharmacopoeia (BP) Reference Standard

象形图

GHS07,GHS08

警示用语：

Warning

危险声明

H302 - H336 - H361d - H412

预防措施声明

P201 - P273 - P301 + P312 + P330 - P308 + P313

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3

靶器官

Central nervous system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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Serotonergic, brain volume and attentional correlates of trait anxiety in primates.

Yevheniia Mikheenko et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(6), 1395-1404 (2015-01-15)

Trait anxiety is a risk factor for the development and maintenance of affective disorders, and insights into the underlying brain mechanisms are vital for improving treatment and prevention strategies. Translational studies in non-human primates, where targeted neurochemical and genetic manipulations

Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality.

Gordon F Buchanan et al.

The Journal of physiology, 592(19), 4395-4410 (2014-08-12)

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Defects in central control of breathing are important contributors to the pathophysiology of SUDEP, and serotonin (5-HT) system dysfunction may be involved. Here

Serotonin 2C receptor antagonists induce fast-onset antidepressant effects.

M D Opal et al.

Molecular psychiatry, 19(10), 1106-1114 (2013-10-30)

Current antidepressants must be administered for several weeks to produce therapeutic effects. We show that selective serotonin 2C (5-HT2C) antagonists exert antidepressant actions with a faster-onset (5 days) than that of current antidepressants (14 days) in mice. Subchronic (5 days)

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk.

Mark R Davies et al.

Cell reports. Medicine, 1(5), 100076-100076 (2020-11-19)

There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose use of high-throughput in vitro data combined with computational models

Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action.

Jesper T Andreasen et al.

Brain research, 1601, 117-126 (2015-01-13)

Depression and anxiety often co-occur, and conventional monoamine-facilitating antidepressants show efficacy against symptoms in both disorders. Rodent studies indicate that antidepressant effects of monoamine-based antidepressants involve increased α-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid glutamate receptor (AMPAR) neurotransmission, and positive allosteric modulators (PAMs) at

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氢溴酸西酞普兰 氢溴酸盐