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Merck
CN

1218005

USP

苯海拉明 盐酸盐

United States Pharmacopeia (USP) Reference Standard

别名:

2-二苯基甲氧基- N , N -二甲基乙胺 盐酸盐, N -(2-二苯基甲氧基乙基)- N , N -二甲胺 盐酸盐

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关于此项目

经验公式(希尔记法):
C17H21NO · HCl
CAS Number:
分子量:
291.82
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
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等级

pharmaceutical primary standard

API类

diphenhydramine

制造商/商品名称

USP

应用

pharmaceutical (small molecule)

包装形式

neat

SMILES字符串

Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2

InChI

1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

InChI key

PCHPORCSPXIHLZ-UHFFFAOYSA-N

基因信息

human ... HRH1(3269)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Diphenhydramine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Acetaminophen, Diphenhydramine Hydrochloride, and Pseudoephedrine Hydrochloride Tablets
  • Dimenhydrinate
  • Dimenhydrinate Tablets
  • Diphenhydramine and Phenylephrine Hydrochlorides Tablets
  • Diphenhydramine and Pseudoephedrine Capsules
  • Diphenhydramine Hydrochloride
  • Diphenhydramine Hydrochloride and Ibuprofen Capsules

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Takashi Koyanagi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(10), 893-901 (2014-03-22)
1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydramine (hepatic blood flow-limited and alpha-1 acid glycoprotein bound) and ofloxacin (renally eliminated) were evaluated in
Olabisi Oduwole et al.
The Cochrane database of systematic reviews, 12(12), CD007094-CD007094 (2014-12-24)
Cough causes concern for parents and is a major cause of outpatient visits. It can impact on quality of life, cause anxiety and affect sleep in parents and children. Several remedies, including honey, have been used to alleviate cough symptoms.
Makiko Kido-Nakahara et al.
The Journal of clinical investigation, 124(6), 2683-2695 (2014-05-09)
In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein-coupled receptor endothelin A receptor (ETAR). Here, we have
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Andrew Curtright et al.
PloS one, 10(1), e0116766-e0116766 (2015-01-15)
Acute and chronic pain conditions are often debilitating, inflicting severe physiological, emotional and economic costs and affect a large percentage of the global population. However, the development of therapeutic analgesic agents based primarily on targeted drug development has been largely

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