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Merck
CN

1268808

USP

依托泊苷

United States Pharmacopeia (USP) Reference Standard

别名:

4′-去甲基表鬼臼毒素 -(4,6-O-亚乙基-β-D-吡喃葡萄糖苷), VP-16-213

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关于此项目

经验公式（希尔记法）:
C29H32O13
化学文摘社编号:
33419-42-0
分子量:
588.56
NACRES:
NA.24
PubChem Substance ID:
329749817
UNSPSC Code:
41116107
MDL number:
MFCD00869325

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InChI

1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

SMILES string

COc1cc(cc(OC)c1O)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26

InChI key

VJJPUSNTGOMMGY-MRVIYFEKSA-N

grade

pharmaceutical primary standard

API family

etoposide

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... TOP2A(7153), TOP2B(7155)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Etoposide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Etoposide Capsules
  • Etoposide Injection
  • Etoposide Phosphate
  • Etoposide Phosphate for Injection

Biochem/physiol Actions

依托泊甙是一种抗肿瘤试剂，和拓扑异构酶II和DNA结合，增强DNA双链和单链剪切和可逆抑制解除。 在S期和G2期阻止细胞周期；诱导正常和肿瘤细胞系凋亡；抑制癌蛋白Mdm2的合成，引起Mdm2过量表达的肿瘤系细胞凋亡。
抗肿瘤试剂，和拓扑异构酶II和DNA结合，增强DNA双链和单链剪切和可逆抑制解除。

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Repr. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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